Single Cell Sequencing Analysis of Thymoma

NCT ID: NCT04162691

Last Updated: 2023-01-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

10 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-06-06

Study Completion Date

2023-12-31

Brief Summary

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The purpose of this study is to understand how genetics play a role in thymoma. Intratumoral heterogeneity is among the greatest challenges in precision cancer therapy. However, developments in high-throughput single-cell RNA sequencing (scRNA-seq) may now provide the statistical power to dissect the diverse cellular populations of tumors. This study aims to find out how it affects genetic and protein expression in patients with malignant thymoma, compared to Benign thymoma, at a single-cell level using a flow cytometry and RNA-sequencing protocol.

Detailed Description

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Conditions

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Thymoma

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Malignant thymoma

Tissue

Intervention Type DIAGNOSTIC_TEST

Four 4-5 mm tissues of the thymoma

Benign thymoma

Tissue

Intervention Type DIAGNOSTIC_TEST

Four 4-5 mm tissues of the thymoma

Interventions

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Tissue

Four 4-5 mm tissues of the thymoma

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Patients diagnosed with thymoma
* Ability to provide written consent and comply with the protocol
* At least 18 years of age

Exclusion Criteria

* Patients undergoing thymoma treatment
* Patients with previous malignancy
* Known HIV positive status.
* Evidence of abnormality of any immune cell population from a drug-induced or genetic cause.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Zhejiang Cancer Hospital

OTHER

Sponsor Role lead

Responsible Party

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ZHAO An

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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An Zhao

Hangzhou, , China

Site Status RECRUITING

Countries

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China

Central Contacts

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An ZHAO, MD, PHD

Role: CONTACT

8688122413

Facility Contacts

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An Zhao, Dr

Role: primary

+8618258863556

Other Identifiers

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SCS-001

Identifier Type: -

Identifier Source: org_study_id

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