Studying Genes Associated With Non-Hodgkin Lymphoma in Young Patients
NCT ID: NCT01623856
Last Updated: 2015-05-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
483 participants
OBSERVATIONAL
2012-06-30
2012-06-30
Brief Summary
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Detailed Description
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I. To conduct a preliminary investigation of the effects of loci strongly and consistently associated in prior genome-wide association studies (GWAS) and validation studies of childhood/adolescent acute lymphoblastic leukemia (ALL), adult non-Hodgkin lymphoma (NHL), autoimmune diseases, and atopic diseases on the risk of NHL (lymphoblastic and Burkitt lymphomas) in children and adolescents.
OUTLINE:
DNA samples are analyzed by single nucleotide polymorphism and genotyped by fluorogenic polymerase chain reaction (PCR)-based allelic discrimination (Taqman) assays using the ABI Prism 7900HT reverse transcriptase (RT)-PCR system.
Conditions
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Study Groups
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Observational
DNA samples are analyzed by single nucleotide polymorphism and genotyped by fluorogenic polymerase chain reaction (PCR)-based allelic discrimination (Taqman) assays using the ABI Prism 7900HT reverse transcriptase (RT)-PCR system.
laboratory biomarker analysis
Correlative studies
Interventions
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laboratory biomarker analysis
Correlative studies
Eligibility Criteria
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Inclusion Criteria
* Samples from non-Hispanic white patients
* DNA samples from 384 healthy, anonymous, non-Hispanic white blood donors used as controls
* See Disease Characteristics
* Not specified
20 Years
ALL
Yes
Sponsors
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National Cancer Institute (NCI)
NIH
Children's Oncology Group
NETWORK
Responsible Party
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Principal Investigators
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Amy Linabery, MD
Role: PRINCIPAL_INVESTIGATOR
Children's Oncology Group
Locations
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Children's Oncology Group
Monrovia, California, United States
Countries
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Other Identifiers
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NCI-2012-01975
Identifier Type: REGISTRY
Identifier Source: secondary_id
ANHL12B1
Identifier Type: -
Identifier Source: org_study_id
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