Biomarkers in Tissue Samples From Young Patients With Liver Cancer
NCT ID: NCT01336881
Last Updated: 2016-05-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
99 participants
OBSERVATIONAL
2011-04-30
Brief Summary
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Detailed Description
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I. To identify biomarker signatures associated with hepatoblastoma subtypes (by microRNA array profiling), and their potential correlation with liver developmental stages as well as outcome.
II. To correlate expression array data with copy number array data.
SECONDARY OBJECTIVES:
I. To carry out a focused sequencing interrogation of amplified or deleted genomic regions as well as genes in key cell pathways involved in embryonic development and/or stem cell signaling pathways for which preliminary data suggests involvement in the pathogenesis of hepatoblastoma.
II. To perform whole exome sequencing in a subset of tumors.
OUTLINE: This is a multicenter study.
Archived tumor tissue samples are analyzed for hepatoblastoma and other liver tumor biomarkers by microRNA array profiling and exome sequencing. Results are then compared with patients' clinical data.
Conditions
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Study Design
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RETROSPECTIVE
Study Groups
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Correlative (tissue analysis)
Archived tumor tissue samples are analyzed for hepatoblastoma and other liver tumor biomarkers by microRNA array profiling and exome sequencing. Results are then compared with patients' clinical data.
RNA analysis
gene expression analysis
microarray analysis
nucleic acid sequencing
diagnostic laboratory biomarker analysis
Interventions
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RNA analysis
gene expression analysis
microarray analysis
nucleic acid sequencing
diagnostic laboratory biomarker analysis
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Pure fetal histology
* Transitional histology
* Small cell undifferentiated histology
* Participated on the Children's Oncology Group (COG) clinical trials
* Available data and tumor samples
16 Years
ALL
No
Sponsors
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National Cancer Institute (NCI)
NIH
Children's Oncology Group
NETWORK
Responsible Party
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Principal Investigators
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Gail Tomlinson, MD
Role: PRINCIPAL_INVESTIGATOR
Children's Oncology Group
Locations
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Children's Oncology Group
Monrovia, California, United States
Countries
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Other Identifiers
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NCI-2011-02852
Identifier Type: REGISTRY
Identifier Source: secondary_id
COG-AHEP11B1
Identifier Type: OTHER
Identifier Source: secondary_id
CDR0000698720
Identifier Type: OTHER
Identifier Source: secondary_id
AHEP11B1
Identifier Type: -
Identifier Source: org_study_id
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