Biomarkers in Tumor Samples From Younger Patients With Neuroblastoma
NCT ID: NCT01493830
Last Updated: 2016-07-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
5 participants
OBSERVATIONAL
2011-12-31
Brief Summary
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PURPOSE: This research trial studies biomarkers in tumor samples from younger patients with neuroblastoma.
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Detailed Description
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* To determine the expression of UBE4B, hrs, and members of the ubiquitination protein complex in previously banked primary neuroblastoma tumor samples from the Children's Oncology Group.
* To determine the correlation of expression levels and cellular localization of the UBE4B and hrs proteins with growth factor-receptor tumor cell-surface expression.
* To determine the 1p36 deletion status by fluorescence in situ hybridization (FISH) analysis and their association with expression levels of UBE4B and hrs in previously banked primary neuroblastoma tumor samples from the Children's Oncology Group.
OUTLINE: Banked tumor tissue samples are analyzed for expression of UBE4B, hrs, members of the ubiquitination protein complex, growth factor receptors, and 1p36 deletion status by immunohistochemistry (IHC), fluorescent microscopy, and fluorescence in situ hybridization (FISH).
Conditions
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Study Design
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CASE_ONLY
RETROSPECTIVE
Interventions
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fluorescence in situ hybridization
gene expression analysis
microarray analysis
mutation analysis
protein analysis
immunohistochemistry staining method
laboratory biomarker analysis
microscopy
Eligibility Criteria
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Inclusion Criteria
* Tumor tissue microarrays from the Children's Oncology Group neuroblastoma tumor bank
PATIENT CHARACTERISTICS:
* Not specified
PRIOR CONCURRENT THERAPY:
* Not specified
120 Years
ALL
No
Sponsors
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National Cancer Institute (NCI)
NIH
Children's Oncology Group
NETWORK
Responsible Party
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Principal Investigators
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Peter Zage, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Texas Children's Cancer Center
Other Identifiers
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COG-ANBL12B4
Identifier Type: OTHER
Identifier Source: secondary_id
NCI-2012-00091
Identifier Type: REGISTRY
Identifier Source: secondary_id
ANBL12B4
Identifier Type: OTHER
Identifier Source: secondary_id
ANBL12B4
Identifier Type: -
Identifier Source: org_study_id
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