Studying Protein Expression in Tissue Samples From Younger Patients With Rhabdomyosarcoma
NCT ID: NCT01609803
Last Updated: 2016-05-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
99 participants
OBSERVATIONAL
2012-06-30
2016-05-31
Brief Summary
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Detailed Description
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I. To investigate (in two stages) which proteins are overexpressed in association with 12q13-q14 amplification by applying fluorescence in situ hybridization (FISH) and immunohistochemical (IHC) assays to a panel of alveolar rhabdomyosarcomas (ARMS) cases organized into tissue microarrays.
OUTLINE:
Formalin-fixed paraffin-embedded tissue samples are analyzed for 12q13-q14 frequency and protein overexpression by FISH and IHC.
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Correlative studies
Formalin-fixed paraffin-embedded tissue samples are analyzed for 12q13-q14 frequency and protein overexpression by FISH and IHC.
laboratory biomarker analysis
Correlative studies
Interventions
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laboratory biomarker analysis
Correlative studies
Eligibility Criteria
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Inclusion Criteria
* PAX3-FOXO1-positive tumors
* PAX7-FOXO1-positive tumors
* Fusion-negative tumors
21 Years
ALL
No
Sponsors
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National Cancer Institute (NCI)
NIH
Children's Oncology Group
NETWORK
Responsible Party
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Principal Investigators
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Frederick Barr, MD
Role: PRINCIPAL_INVESTIGATOR
Children's Oncology Group
Locations
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Children's Oncology Group
Monrovia, California, United States
Countries
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Other Identifiers
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NCI-2012-01972
Identifier Type: REGISTRY
Identifier Source: secondary_id
COG-ARST12B7
Identifier Type: OTHER
Identifier Source: secondary_id
ARST12B7
Identifier Type: -
Identifier Source: org_study_id
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