Establishing a Tumor Bank in Families With Multiple Lymphoproliferative Malignancies

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2004-08-09

Study Completion Date

2033-01-31

Brief Summary

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The purpose of this study is to investigate possible genetic factors that contribute to the development of lymphomas. The databank will be used to determine whether familial lymphomas have unique genetic characteristics different from sporadic lymphomas and to attempt to identify a gene that confers an increased risk of lymphoma.

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Detailed Description

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* Patients who participate will be asked to complete detailed family and medical history questionnaires initially, with a follow-up questionnaire every year.
* Patients will be asked to supply a blood sample and possibly a mouthwash sample, both of which can be done by mail.
* Patients will be asked to consent to the release of their lymphoma tissue block for the purposes of the study.
* Patients will be given letters of invitation for their affected relatives to invite them to participate.

Conditions

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Non-Hodgkin's Lymphoma Hodgkin's Disease Leukemia, Lymphocytic, Chronic Lymphoproliferative Disorders

Study Design

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Observational Model Type

FAMILY_BASED

Study Time Perspective

PROSPECTIVE

Study Groups

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Next of Kin of deceased subj by lymphoma

Next of Kin of deceased subject by lymphoma

No interventions assigned to this group

Subject unaffected by lymphoma

No interventions assigned to this group

Subject affected by lymphoma

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Any individual diagnosed with non-Hodgkin's lymphoma or Hodgkin's disease or chronic lymphocytic leukemia (CLL), who has a 1st degree relative (parent, sibling or child) with a lymphoproliferative disorder; or families in which the individual has a lymphoproliferative disorder, and an unusual clustering of frequent or premature solid tumors is also observed.
* Family members of the individual, either affected or unaffected with lymphoma, who are contacted by the individual and agree to participate in the study.
* Deceased family members may be included in the study. Public records such as death certificates may be used to confirm the history. Consent for medical records or tissue blocks will be obtained from the deceased family member's next of kin. The hierarchy of relatives defined as next of kin is spouse, offspring, parents and siblings. Archived tissue samples may be used for genetic research.
* Age \> 18 years