Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
32 participants
OBSERVATIONAL
2016-06-30
2024-06-30
Brief Summary
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Detailed Description
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2. Clinical information, examination data: Information is obtained from medical record abstraction.
3. Samples: Fresh frozen thyroid tissues from each sample group(normal histology, benign disease, papillary thyroid carcinoma with cervical lymph node metastasis, papillary thyroid carcinoma without cervical lymph node metastasis ).
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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PTC group 1
papillary thyroid carcinoma patients with cervical lymph node metastasis
No interventions assigned to this group
PTC group 2
papillary thyroid carcinoma patients without cervical lymph node metastasis
No interventions assigned to this group
Positive control group
benign disease
No interventions assigned to this group
Negative control group
histologically normal
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Undergo thyroidectomy according to the China thyroid association guidelines forthe Management of thyroid nodule and thyroid cancer.
Exclusion Criteria
* Daily tobacco and alcohol use.
* Whole neck irradiation or surgery.
* Prior cancer diagnosis or chemotherapy treatment.
* Active autoimmune disorder.
* Uncontrolled allergic condition or asthma.
* Chronic use of oral steroid medication.
* Hormone therapy (estrogen, progestin compounds).
18 Years
65 Years
ALL
No
Sponsors
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The Affiliated Hospital of Inner Mongolia Medical University
OTHER
Responsible Party
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Principal Investigators
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Shan Jin, PhD
Role: STUDY_DIRECTOR
The Affiliated Hospital of Inner Mongolia Medical University
Locations
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Shan Jin
Hohhot, Inner Mongolia, China
Countries
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Central Contacts
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Facility Contacts
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References
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Gharib H, Papini E. Thyroid nodules: clinical importance, assessment, and treatment. Endocrinol Metab Clin North Am. 2007 Sep;36(3):707-35, vi. doi: 10.1016/j.ecl.2007.04.009.
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid. 2016 Jan;26(1):1-133. doi: 10.1089/thy.2015.0020.
Brown LM, Helmke SM, Hunsucker SW, Netea-Maier RT, Chiang SA, Heinz DE, Shroyer KR, Duncan MW, Haugen BR. Quantitative and qualitative differences in protein expression between papillary thyroid carcinoma and normal thyroid tissue. Mol Carcinog. 2006 Aug;45(8):613-26. doi: 10.1002/mc.20193.
Sofiadis A, Becker S, Hellman U, Hultin-Rosenberg L, Dinets A, Hulchiy M, Zedenius J, Wallin G, Foukakis T, Hoog A, Auer G, Lehtio J, Larsson C. Proteomic profiling of follicular and papillary thyroid tumors. Eur J Endocrinol. 2012 Apr;166(4):657-67. doi: 10.1530/EJE-11-0856. Epub 2012 Jan 24.
Other Identifiers
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AHInnerMongolia-Thyroid-02
Identifier Type: -
Identifier Source: org_study_id
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