Association Between Mitochondrial DNA Content and Risk of Gastric Cancer

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

600 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-03-31

Study Completion Date

2016-09-30

Brief Summary

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Compelling epidemiological evidence indicates that alterations of mitochondrial DNA, including mutations and abnormal content of mitochondrial DNA (mtDNA), are associated with the initiation and development of gastric cancer.The aim of this study was to explore association between mtDNA content in peripheral blood cells could be used as a risk predictor for gastric cancer.

Detailed Description

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Conditions

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Stomach Neoplasms

Keywords

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Mitochondrial DNA copy number Gastric cancer

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Gastric cancer group

300 consecutive patients were recruited, who have diagnosed with gastric cancer by biopsy

No interventions assigned to this group

Control group

The 300 healthy controls without previous cancer history were recruited from individuals who visited investigator's hospital for physical examination during the same time period as the case enrollment.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* 1.histological confirmed gastric adenocarcinoma; 2.receiving surgical resection; 3.no preoperative anticancer treatment; 4.alive at least 1 months after surgery.

Exclusion Criteria

* 1.history of other malignancy; 2.blood transfusion within one month or prior bone marrow transplantation; 3.patients who reluctant to sign informed consent.

Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Wenyi Guo

Professor of Department of Cardiology of Xijing Hospital

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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ZJ20161024

Identifier Type: -

Identifier Source: org_study_id