Exploration of High Frequency Otoacoustic Emissions and Developmental Language Disorders

NCT ID: NCT05624983

Last Updated: 2022-11-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

138 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-01-01

Study Completion Date

2027-07-01

Brief Summary

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Among the objective non-invasive audiological explorations the distorsion products of otoacoustic emissions (DPOAE) allow to quickly assess the function of the cochlear outer hair cells (without the active participation of the subject). This technique is used in newborn screening. While humans are able to perceive sounds in a frequency range of 20Hz to 20kHz, routine clinical audiological assessment is only concerned with frequencies between 1-4kHz.

This obscures the importance of high frequencies (HF) which can be easily assessed by DPOAEs. In young children, the perception of these high frequencies could also play an important role in language acquisition.

The main objective of this study is to evaluate the relationship between subtle high-frequency hearing impairment, as assessed by the DPOAE (non-invasive, rapid and simple audiological test), and language delay or difficulties in a pre-, peri- and school-age pediatric population.

Detailed Description

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Conditions

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Language Development Disorders

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

one group of cases (children with language disorder) one group of control (children without language disorder)
Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Case group (children with language disorder)

Hearing diagnostic test

Group Type EXPERIMENTAL

acoustic otoemisions

Intervention Type DIAGNOSTIC_TEST

TOAE and DPOAE

Otoscopy

Intervention Type DIAGNOSTIC_TEST

presence of earwax checked by video otoscop

Audiometry

Intervention Type DIAGNOSTIC_TEST

Hearing Threshold will be measured with the AD528 interacoustics

Tympanometry

Intervention Type DIAGNOSTIC_TEST

Tympanic mobility will be measyred with the Titan interacoustics

controle group (children without language disorder)

Hearing diagnostic test

Group Type OTHER

acoustic otoemisions

Intervention Type DIAGNOSTIC_TEST

TOAE and DPOAE

Otoscopy

Intervention Type DIAGNOSTIC_TEST

presence of earwax checked by video otoscop

Audiometry

Intervention Type DIAGNOSTIC_TEST

Hearing Threshold will be measured with the AD528 interacoustics

Tympanometry

Intervention Type DIAGNOSTIC_TEST

Tympanic mobility will be measyred with the Titan interacoustics

Interventions

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acoustic otoemisions

TOAE and DPOAE

Intervention Type DIAGNOSTIC_TEST

Otoscopy

presence of earwax checked by video otoscop

Intervention Type DIAGNOSTIC_TEST

Audiometry

Hearing Threshold will be measured with the AD528 interacoustics

Intervention Type DIAGNOSTIC_TEST

Tympanometry

Tympanic mobility will be measyred with the Titan interacoustics

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Normal hearing (after an audiometry test, even if an ENT consultation has been carried out beforehand and if the doctor has not found any hearing problem, as defined in the NF EN ISO 70292017-04 standard, and according to an average hearing loss calculated according to the BIAP \<20dB HL)
* Free and informed consent of the parental authority and the patient
* Affiliated to the social security system
* Presenting a developmental language acquisition disorder (score according to the EVALO / EVALEO test)
* For children between 15 and 17 years of age, completion of the EVALEO test before their 16th birthday


* Normal hearing (after an audiometry test, even if an ENT consultation has been performed beforehand and if the doctor has not found any hearing problem, as defined in the NF EN ISO 70292017-04 standard, and according to an average hearing loss calculated according to the BIAP \<20dB HL)
* Free and informed consent of the parental authority and the patient
* Enrolled in the social security system

Exclusion Criteria

* Hearing disorder identified during the inclusion visit (presence of cerumen or foreign body in the earwax plug or foreign body in the external auditory canal, tympanometry suggesting a middle ear disorder, audiometry with thresholds outside the normal thresholds outside the normal range (0-20dB HL), absence of responses in (0-20dB HL), absence of responses in acoustic otoemissions or acoustic distortion products) on conversational frequencies between 500Hz and 4kHz.
* Declaration by the parents of an ENT follow-up for a hearing disorder and/or a speech therapy for a language disorder
* Refusal of participation evoked by the subject
Minimum Eligible Age

2 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Clermont-Ferrand

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CHU Clermont-Ferrand, UMR INSERM 1107

Clermont-Ferrand, , France

Site Status

Countries

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France

Central Contacts

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Lise Laclautre

Role: CONTACT

04 73 75 11 95

Facility Contacts

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Lise Laclautre

Role: primary

04 73 75 11 95

Other Identifiers

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RBHP 2022 SARRET

Identifier Type: -

Identifier Source: org_study_id

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