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Characterization of Auditory Processing Involved in the Encoding of Speech Sounds

NCT ID: NCT02574299

Last Updated: 2025-12-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-10-16

Study Completion Date

2018-03-01

Brief Summary

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The ability to encode the speech signal is determined by ascending and descending auditory processing. Difficulties in processing these speech signals are well described at the behavioral level in a specific language disorder. However, little is known about the underlying pathophysiological mechanisms. The assumption is that we should observe a degradation of the signal provided by the ear in the deaf subject while in case of specific language impairment it would be a phonemic disorder (possibly linked to a processing disorder auditory). The two population groups should therefore have different abnormalities of their central auditory process - which could be modified by the target remediation for each group.

Detailed Description

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Conditions

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Language Impairment Hearing Loss

Keywords

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dyslexia training auditory rehabilitation hearing loss evoked potentials dichotic plasticity noise

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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1: Normal hearing children without SLI, transversal group

Normal hearing children without Specific Language Impairment (SLI),Transversal group for test-retest measures

Group Type NO_INTERVENTION

No interventions assigned to this group

2: Normal hearing children without SLI, longitudinal group

Normal hearing children without Specific Language Impairment (SLI), longitudinal group without training

Group Type NO_INTERVENTION

No interventions assigned to this group

3: Normal hearing children with SLI, longitudinal group

Normal hearing children with Specific Language Impairment (SLI), longitudinal group with training

Group Type OTHER

E-learning

Intervention Type OTHER

Management of auditory processing disorders with serious game (E-learning)

4: Normal hearing adults without SLI, transversal group

Normal hearing adults without Specific Language Impairment (SLI), transversal group for test-retest measures

Group Type NO_INTERVENTION

No interventions assigned to this group

5: Normal hearing adults without SLI, longitudinal group

Normal hearing adults without Specific Language Impairment (SLI), longitudinal group without hearing aids (HA)

Group Type NO_INTERVENTION

No interventions assigned to this group

6: Hearing Impaired candidates for HA, longitudinal group

Hearing Impaired adult candidates for hearing aids (HA), longitudinal group with hearing aids (HA)

Group Type OTHER

Hearing aids fitting

Intervention Type DEVICE

Symmetrical hearing loss which are fitted with binaural hearing aids for the first time

Interventions

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E-learning

Management of auditory processing disorders with serious game (E-learning)

Intervention Type OTHER

Hearing aids fitting

Symmetrical hearing loss which are fitted with binaural hearing aids for the first time

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

For all subjects:

* native French speaker
* no medical treatment for behavior or neurological disorders
* normal or corrected vision
* right-handed
* normal otorhinolaryngology examination
* valid affiliation to social security
* no participation to another research study

For the normal-hearing subjects

* normal tonal hearing thresholds
* normal tympanometry

For the subjects without specific language impairment

* aged from 6 ro 40
* normal school attendance without scholastic retardation
* normal intellectual level
* normal for age reading skills
* no delayed speech (expression \& production)

For the children with specific language impairment

* aged fom 8 to 18
* persistent specific literacy difficulties with reading levels at least 18 months behind that of their peers
* normal intellectual level

For the hearing impaired subjects

* age from 18 to 70
* first auditory rehabilitation
* bilateral and symmetric hearing loss (±10 dB) with hearing thresholds between 0 and 25 dB at 0.25 kilohertz, 0 and 35 dB at 0.5 kilohertz, 0 and 50 dB at 1 kilohertz, 25 and 70 dB at 2 kilohertz, 25 and 80 dB at 3 kilohertz, 30 and 80 dB at 4 kilohertz

Exclusion Criteria

* non signed assent
* treatment for depression, epilepsy, Parkinson's or alzheimer's disease during more than 6 months
* physical health deficiency
* mental retardation
* neurological or psychiatric disease incompatible with testing procedure

For children

* known problem of hearing loss or chronic middle ear disease whic compromized the hearing status
* schooling in a foreign language
* foreign language spoken at home with both parents
Minimum Eligible Age

6 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Sercive d'Audiologie et d'Exploration Orofaciales, Hôpital Edouard Herriot, Hospices Civils de Lyon

Lyon, , France

Site Status

Countries

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France

References

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Reynard P, Veuillet E, Thai-Van H. Paradoxical and labile medial olivocochlear functioning as a potential marker of auditory processing disorder in a child with learning disabilities. Eur Ann Otorhinolaryngol Head Neck Dis. 2020 Sep;137(4):339-342. doi: 10.1016/j.anorl.2020.03.005. Epub 2020 Apr 1.

Reference Type RESULT
PMID: 32247718 (View on PubMed)

Bellier L, Bouchet P, Jeanvoine A, Valentin O, Thai-Van H, Caclin A. Topographic recordings of auditory evoked potentials to speech: subcortical and cortical responses. Psychophysiology. 2015 Apr;52(4):594-9. doi: 10.1111/psyp.12369. Epub 2014 Oct 20.

Reference Type RESULT
PMID: 25329609 (View on PubMed)

Bellier L, Veuillet E, Vesson JF, Bouchet P, Caclin A, Thai-Van H. Speech Auditory Brainstem Response through hearing aid stimulation. Hear Res. 2015 Jul;325:49-54. doi: 10.1016/j.heares.2015.03.004. Epub 2015 Mar 27.

Reference Type RESULT
PMID: 25828076 (View on PubMed)

Other Identifiers

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ID-RCB

Identifier Type: OTHER

Identifier Source: secondary_id

2013-796

Identifier Type: -

Identifier Source: org_study_id