Motivations to Transplant Registry Participation

NCT ID: NCT05595382

Last Updated: 2025-04-18

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

397 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-10-10

Study Completion Date

2023-11-06

Brief Summary

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The current study seeks to understand factors that influence college students' likelihood of participating the National Marrow Donor Program (NMDP)/Be the Match for bone marrow and stem cell donations. The secondary aim is to compare emotional and rational approaches to encouraging participation in the registry and how these approaches may impact intentions to participate in the NMDP.

Detailed Description

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This study is a randomized controlled trial that will randomize participants to receive either an emotional appeal about a child with cancer who needs a bone marrow transplant or a rational appeal using data on the racial/ethnic disparities within the transplant registry.

Participants will be recruited through the Psychology Subject Pool, which will then link students to the study measures in an online survey. Participants will be asked their age to confirm eligibility to participate (students must be between 18-35), and eligible students will be presented with the consent form through the online survey system. Participants will then be asked to complete measures of demographic information, personality/psychological characteristics, and transplant-related knowledge, intentions, and attitudes. All participants will then be given background information on bone marrow transplants.

Randomization: Students will be randomized by sex in the online survey system to the emotional presentation condition or the rational presentation condition. The emotional condition will tell the story of a fictional pediatric patient with cancer who needs a transplant. The rational condition will describe the facts about the need for diversity in the registry.

After being presented with the rational or emotional appeal, participants will again be asked about their intentions to register, their motivations for registering, and their mood.

Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

SINGLE

Participants

Study Groups

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Emotional Group

Participants will be randomly assigned to receive an emotional or rational appeal, stratified by sex.

Group Type EXPERIMENTAL

Emotional Appeal

Intervention Type BEHAVIORAL

Participants will be presented with a short vignette about a child undergoing cancer treatment and needing a bone marrow transplant in order to survive cancer.

Rational Group

Participants will be randomly assigned to receive an emotional or rational appeal, stratified by sex.

Group Type EXPERIMENTAL

Rational Appeal

Intervention Type BEHAVIORAL

Participants will be presented with data regarding the importance of considering race/ethnicity when looking for a bone marrow transplant donor and the likelihood of finding a match based on the patient's racial/ethnic background.

Interventions

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Emotional Appeal

Participants will be presented with a short vignette about a child undergoing cancer treatment and needing a bone marrow transplant in order to survive cancer.

Intervention Type BEHAVIORAL

Rational Appeal

Participants will be presented with data regarding the importance of considering race/ethnicity when looking for a bone marrow transplant donor and the likelihood of finding a match based on the patient's racial/ethnic background.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Rutgers Camden Students enrolled in Psych 101 and Method and Theory
* Between the ages of 18-35

Exclusion Criteria

* Students under 18 years of age or over 36 or older will be excluded.
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Rutgers, The State University of New Jersey

OTHER

Sponsor Role lead

Responsible Party

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Lauren C. Daniel, Ph.D.

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Lauren C Daniel, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Rutgers University

Locations

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Rutgers University Camden

Camden, New Jersey, United States

Site Status

Countries

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United States

References

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Billen A, Madrigal JA, Scior K, Shaw BE, Strydom A. Donation of peripheral blood stem cells to unrelated strangers: A thematic analysis. PLoS One. 2017 Oct 25;12(10):e0186438. doi: 10.1371/journal.pone.0186438. eCollection 2017.

Reference Type BACKGROUND
PMID: 29069088 (View on PubMed)

Butterworth VA, Simmons RG, Bartsch G, Randall B, Schimmel M, Stroncek DF. Psychosocial effects of unrelated bone marrow donation: experiences of the National Marrow Donor Program. Blood. 1993 Apr 1;81(7):1947-59.

Reference Type BACKGROUND
PMID: 8461479 (View on PubMed)

CROWNE DP, MARLOWE D. A new scale of social desirability independent of psychopathology. J Consult Psychol. 1960 Aug;24:349-54. doi: 10.1037/h0047358. No abstract available.

Reference Type BACKGROUND
PMID: 13813058 (View on PubMed)

Fingrut W, Parmar S, Cuperfain A, Rikhraj K, Charman E, Ptak E, Kahlon M, Graham A, Luong S, Wang YG, Yu J, Arora N, Suppiah R, Li EW, Lee A, Welsh C, Benzaquen M, Thatcher A, Baharmand I, Ladd A, Petraszko T, Allan D, Messner H. The Stem Cell Club: a model for unrelated stem cell donor recruitment. Transfusion. 2017 Dec;57(12):2928-2936. doi: 10.1111/trf.14327. Epub 2017 Sep 24.

Reference Type BACKGROUND
PMID: 28944484 (View on PubMed)

Gardner, Paul. (1987). Measuring ambivalence to science. Journal of Research in Science Teaching. 24. 241 - 247. 10.1002/tea.3660240305.

Reference Type BACKGROUND

Kaster EC, Rogers CR, Jeon KC, Rosen B. Getting to the Heart of Being the Match: A Qualitative Analysis of Bone Marrow Donor Recruitment and Retention Among College Students. Health Educ (Muncie). 2014 Spring;46(1):14-19.

Reference Type BACKGROUND
PMID: 25632376 (View on PubMed)

Monaghan M, Yi QL, Green M, Campbell T, Weiss JT, Dibdin N, Mercer D, Elmoazzen H, Allan DS. Factors associated with registrant availability for unrelated adult donor hematopoietic stem cell donation: Analysis of the stem cell registry at Canadian Blood Services. Transfusion. 2021 Jan;61(1):24-28. doi: 10.1111/trf.16129. Epub 2020 Oct 21.

Reference Type BACKGROUND
PMID: 33084098 (View on PubMed)

Narayanan P, Wolanskyj A, Ehlers SL, Litzow MR, Patnaik MS, Hogan WJ, Hashmi SK. Medical Students' Knowledge, Familiarity, and Attitudes towards Hematopoietic Stem Cell Donation: Stem Cell Donation Behaviors. Biol Blood Marrow Transplant. 2016 Sep;22(9):1710-1716. doi: 10.1016/j.bbmt.2016.06.014. Epub 2016 Jun 22.

Reference Type BACKGROUND
PMID: 27343721 (View on PubMed)

National Marrow Donor Program (2013). Key Figures and Facts. www.bethematch.com

Reference Type BACKGROUND

Onitilo AA, Lin YH, Okonofua EC, Afrin LB, Ariail J, Tilley BC. Race, education, and knowledge of bone marrow registry: indicators of willingness to donate bone marrow among African Americans and Caucasians. Transplant Proc. 2004 Dec;36(10):3212-9. doi: 10.1016/j.transproceed.2004.10.019.

Reference Type BACKGROUND
PMID: 15686731 (View on PubMed)

Rose A, Peters N, Shea JA, Armstrong K. Development and testing of the health care system distrust scale. J Gen Intern Med. 2004 Jan;19(1):57-63. doi: 10.1111/j.1525-1497.2004.21146.x.

Reference Type BACKGROUND
PMID: 14748861 (View on PubMed)

Rosenberg, M. (1965). Rosenberg self-esteem scale. Journal of Religion and Health.

Reference Type BACKGROUND

Rushton, J. P., Chrisjohn, R. D., & Fekken, G. C. (1981). The altruistic personality and the self-report altruism scale. Personality and individual differences, 2(4), 293-302.

Reference Type BACKGROUND

Surana, P. K., & Lomas, T. (2014). The power of charity: Does giving away money improve the wellbeing of the donor. Indian Journal of Positive Psychology, 5(3), 223-230.

Reference Type BACKGROUND

Studts JL, Ruberg JL, McGuffin SA, Roetzer LM. Decisions to register for the National Marrow Donor Program: rational vs emotional appeals. Bone Marrow Transplant. 2010 Mar;45(3):422-8. doi: 10.1038/bmt.2009.174. Epub 2009 Aug 3.

Reference Type BACKGROUND
PMID: 19648972 (View on PubMed)

Vasconcellos A, Nunes A, Feller E. Knowledge, attitudes, and behaviors regarding the bone marrow registry among college and medical students in Rhode Island. Med Health R I. 2011 Oct;94(10):302-5. No abstract available.

Reference Type BACKGROUND
PMID: 22164662 (View on PubMed)

Vekaria KM, Hammell AE, Vincent L, Smith M, Rogers T, Switzer GE, Marsh AA. The role of prospection in altruistic bone marrow donation decisions. Health Psychol. 2020 Apr;39(4):316-324. doi: 10.1037/hea0000819. Epub 2019 Nov 14.

Reference Type BACKGROUND
PMID: 31724423 (View on PubMed)

Daniel LC, Elias G, Shah P, Kokolis N. Increasing participation in the national marrow donor program: A randomized trial. J Health Psychol. 2025 Sep 28:13591053251367869. doi: 10.1177/13591053251367869. Online ahead of print.

Reference Type DERIVED
PMID: 41015944 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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Pro2022000536

Identifier Type: -

Identifier Source: org_study_id

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