Trial Outcomes & Findings for Motivations to Transplant Registry Participation (NCT NCT05595382)
NCT ID: NCT05595382
Last Updated: 2025-04-18
Results Overview
Participants rated the likelihood of registering on a 1-7 scale with higher scores indicating greater intention to join the registry (better outcome). Participants were asked these questions before (baseline) and after (post-intervention) the experimental manipulation.
COMPLETED
NA
397 participants
Baseline and after the experimental manipulation (Post-Intervention)
2025-04-18
Participant Flow
Participants were randomized after completing study baseline measures. 36 participants dropped out before reaching randomization.
Participant milestones
| Measure |
Emotional Group
Participants will be randomly assigned to receive an emotional or rational appeal, stratified by sex.
Emotional Appeal: Participants will be presented with a short vignette about a child undergoing cancer treatment and needing a bone marrow transplant in order to survive cancer.
|
Rational Group
Participants will be randomly assigned to receive an emotional or rational appeal, stratified by sex.
Rational Appeal: Participants will be presented with data regarding the importance of considering race/ethnicity when looking for a bone marrow transplant donor and the likelihood of finding a match based on the patient's racial/ethnic background.
|
|---|---|---|
|
Overall Study
STARTED
|
181
|
180
|
|
Overall Study
COMPLETED
|
181
|
180
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Motivations to Transplant Registry Participation
Baseline characteristics by cohort
| Measure |
Emotional Group
n=181 Participants
Participants will be randomly assigned to receive an emotional or rational appeal, stratified by sex.
Emotional Appeal: Participants will be presented with a short vignette about a child undergoing cancer treatment and needing a bone marrow transplant in order to survive cancer.
|
Rational Group
n=180 Participants
Participants will be randomly assigned to receive an emotional or rational appeal, stratified by sex.
Rational Appeal: Participants will be presented with data regarding the importance of considering race/ethnicity when looking for a bone marrow transplant donor and the likelihood of finding a match based on the patient's racial/ethnic background.
|
Total
n=361 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Continuous
|
19.62 years
STANDARD_DEVIATION 2.62 • n=5 Participants
|
19.71 years
STANDARD_DEVIATION 2.58 • n=7 Participants
|
19.67 years
STANDARD_DEVIATION 2.60 • n=5 Participants
|
|
Sex/Gender, Customized
Female
|
130 Participants
n=5 Participants
|
131 Participants
n=7 Participants
|
261 Participants
n=5 Participants
|
|
Sex/Gender, Customized
Male
|
50 Participants
n=5 Participants
|
49 Participants
n=7 Participants
|
99 Participants
n=5 Participants
|
|
Sex/Gender, Customized
Prefer not to say
|
1 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
1 Participants
n=5 Participants
|
|
Race/Ethnicity, Customized
Race/Ethnicity · Asian
|
31 Participants
n=5 Participants
|
26 Participants
n=7 Participants
|
57 Participants
n=5 Participants
|
|
Race/Ethnicity, Customized
Race/Ethnicity · Black or African American
|
28 Participants
n=5 Participants
|
42 Participants
n=7 Participants
|
70 Participants
n=5 Participants
|
|
Race/Ethnicity, Customized
Race/Ethnicity · Hispanic/Latinx
|
32 Participants
n=5 Participants
|
25 Participants
n=7 Participants
|
57 Participants
n=5 Participants
|
|
Race/Ethnicity, Customized
Race/Ethnicity · Indigenous/Native American
|
3 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
3 Participants
n=5 Participants
|
|
Race/Ethnicity, Customized
Race/Ethnicity · Middle Eastern
|
0 Participants
n=5 Participants
|
3 Participants
n=7 Participants
|
3 Participants
n=5 Participants
|
|
Race/Ethnicity, Customized
Race/Ethnicity · Native Hawaiian
|
0 Participants
n=5 Participants
|
1 Participants
n=7 Participants
|
1 Participants
n=5 Participants
|
|
Race/Ethnicity, Customized
Race/Ethnicity · White
|
52 Participants
n=5 Participants
|
49 Participants
n=7 Participants
|
101 Participants
n=5 Participants
|
|
Race/Ethnicity, Customized
Race/Ethnicity · More than 1 Race/Ethnicity
|
34 Participants
n=5 Participants
|
32 Participants
n=7 Participants
|
66 Participants
n=5 Participants
|
|
Race/Ethnicity, Customized
Race/Ethnicity · Not reported
|
1 Participants
n=5 Participants
|
2 Participants
n=7 Participants
|
3 Participants
n=5 Participants
|
|
Region of Enrollment
United States
|
181 Participants
n=5 Participants
|
180 Participants
n=7 Participants
|
361 Participants
n=5 Participants
|
PRIMARY outcome
Timeframe: Baseline and after the experimental manipulation (Post-Intervention)Population: Likelihood to join registry for all randomized study participants on a 1-7 scale with higher scores indicating a greater likelihood of joining (better outcome).
Participants rated the likelihood of registering on a 1-7 scale with higher scores indicating greater intention to join the registry (better outcome). Participants were asked these questions before (baseline) and after (post-intervention) the experimental manipulation.
Outcome measures
| Measure |
Emotional Group
n=181 Participants
Participants will be randomly assigned to receive an emotional or rational appeal, stratified by sex.
Emotional Appeal: Participants will be presented with a short vignette about a child undergoing cancer treatment and needing a bone marrow transplant in order to survive cancer.
|
Rational Group
n=180 Participants
Participants will be randomly assigned to receive an emotional or rational appeal, stratified by sex.
Rational Appeal: Participants will be presented with data regarding the importance of considering race/ethnicity when looking for a bone marrow transplant donor and the likelihood of finding a match based on the patient's racial/ethnic background.
|
|---|---|---|
|
Intention to Register
Baseline
|
3.32 score on a scale
Standard Error .10
|
3.06 score on a scale
Standard Error .104
|
|
Intention to Register
Post-Intervention
|
4.15 score on a scale
Standard Error 0.113
|
3.27 score on a scale
Standard Error 0.113
|
SECONDARY outcome
Timeframe: Baseline and after experimental manipulation (Post-Intervention)Population: Pre/Post Intervention Mood report for randomized participants. 1 did not complete data.
Participant mood was assessed on a 1-10 scale, with higher scores indicating a better mood. Participants were asked these questions before (baseline) and after (post-intervention) the experimental manipulation.
Outcome measures
| Measure |
Emotional Group
n=181 Participants
Participants will be randomly assigned to receive an emotional or rational appeal, stratified by sex.
Emotional Appeal: Participants will be presented with a short vignette about a child undergoing cancer treatment and needing a bone marrow transplant in order to survive cancer.
|
Rational Group
n=179 Participants
Participants will be randomly assigned to receive an emotional or rational appeal, stratified by sex.
Rational Appeal: Participants will be presented with data regarding the importance of considering race/ethnicity when looking for a bone marrow transplant donor and the likelihood of finding a match based on the patient's racial/ethnic background.
|
|---|---|---|
|
Mood
Baseline
|
6.59 units on a scale
Standard Error .129
|
6.36 units on a scale
Standard Error .130
|
|
Mood
Post-Intervention
|
6.28 units on a scale
Standard Error .137
|
6.18 units on a scale
Standard Error .138
|
SECONDARY outcome
Timeframe: BaselinePopulation: Participant knowledge at baseline (pre-intervention) in all randomized participants
Participants completed a knowledge measure about bone marrow and stem cell transplant donation using true/false statements about transplant donation that was examined as a correlate of their intentions to register with the transplant registry. The measure was scored as a percent of items answered correctly, higher scores indicating better knowledge.
Outcome measures
| Measure |
Emotional Group
n=181 Participants
Participants will be randomly assigned to receive an emotional or rational appeal, stratified by sex.
Emotional Appeal: Participants will be presented with a short vignette about a child undergoing cancer treatment and needing a bone marrow transplant in order to survive cancer.
|
Rational Group
n=180 Participants
Participants will be randomly assigned to receive an emotional or rational appeal, stratified by sex.
Rational Appeal: Participants will be presented with data regarding the importance of considering race/ethnicity when looking for a bone marrow transplant donor and the likelihood of finding a match based on the patient's racial/ethnic background.
|
|---|---|---|
|
Psychosocial and Demographic Correlates of Intentions to Register--Knowledge
|
19.5 percentage of knowledge items correct
Standard Deviation 18.0
|
22.6 percentage of knowledge items correct
Standard Deviation 18.0
|
Adverse Events
Emotional Group
Rational Group
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Dr. Lauren Daniel
Rutgers University Associate Professor
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place