Centralized Cord Blood Registry to Facilitate Unrelated Cord Blood Transplantation

NCT ID: NCT00737516

Last Updated: 2013-06-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

3621 participants

Study Classification

INTERVENTIONAL

Study Start Date

2000-01-31

Study Completion Date

2011-10-31

Brief Summary

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The National Marrow Donor Program (NMDP) has established a system for registering, matching, and tracking unrelated donor cord blood units (CBUs) and transplant outcomes. Study subjects are donors who enroll through collaborating cord blood banks. This study creates uniform collection, screening, testing and storage requirements for cord blood units. The purpose of standardization is to improve efficiency in the selection of cord blood units for transplantation.

Detailed Description

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The NMDP Cord Blood registry is organized as a network of member cord blood banks and transplant centers whose interactions are managed by the NMDP's Center for Cord Blood. Banks agree to comply with uniform collection, screening, testing and storage requirements. Upon approval of membership, cord blood banks submit detailed information on each stored CBU for registration into a proprietary computer system. A transplant center, working on behalf of potential recipients, submits search requests to the NMDP and receives electronic reports detailing potentially suitable CBUs. From these reports, the transplant center selects a CBU(s) for further testing, which includes at a minimum confirmation of the CBUs Human Leukocyte Antigen (HLA) typing data. Upon final selection of the desired CBU for transplantation, arrangements are made for timely shipment of the unit to the transplant center. Following transplantation, recipient outcome data are submitted by the transplant center for addition to the study database.

Conditions

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Leukemia Lymphoma Myelodysplastic Syndromes

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Blinding Strategy

NONE

Study Groups

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single arm

HPC, Cord Blood

Group Type EXPERIMENTAL

HPC, Cord Blood

Intervention Type BIOLOGICAL

Search for HLA compatible cord blood units using the NMDP registry

Interventions

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HPC, Cord Blood

Search for HLA compatible cord blood units using the NMDP registry

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Pregnancy

Exclusion Criteria

\-
Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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National Marrow Donor Program

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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John P Miller, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

National Marrow Donor Program

Locations

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StemCyte International Cord Blood Center

Covina, California, United States

Site Status

Children's Hospital of Orange County Cord Blood Bank

Orange, California, United States

Site Status

Ashley Ross Cord Blood Program

San Diego, California, United States

Site Status

University of Colorado Cord Blood Bank

Aurora, Colorado, United States

Site Status

Bonfils Cord Blood Service

Denver, Colorado, United States

Site Status

Lifeforce Cryobanks

Altamonte Springs, Florida, United States

Site Status

Gift of Life Marrow Foundation

Boca Raton, Florida, United States

Site Status

LifeCord

Gainesville, Florida, United States

Site Status

ITxM Cord Blood Services

Glenview, Illinois, United States

Site Status

J.P. McMarthy Cord Stem Cell Bank

Detroit, Michigan, United States

Site Status

Michigan Community Blood Centers

Grand Rapids, Michigan, United States

Site Status

St. Louis Cord Blood Bank

St Louis, Missouri, United States

Site Status

CBS - New Jersey Cord Blood bank

Allendale, New Jersey, United States

Site Status

Coriell - New Jersey Cord Blood Bank

Camden, New Jersey, United States

Site Status

Carolinas Cord Blood Bank

Durham, North Carolina, United States

Site Status

Cleveland Cord Blood Center

Cleveland, Ohio, United States

Site Status

M.D. Anderson Cord Blood Bank

Houston, Texas, United States

Site Status

Texas Cord Blood Bank

San Antonio, Texas, United States

Site Status

Puget Sound Blood Center

Seattle, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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T00004

Identifier Type: -

Identifier Source: org_study_id

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