The Changes in End Expiratory Lung Impedence Measured by EIT and End Expiratory Lung Volume Measured by Passive Expiratory in Controlled Mechanical Ventilated Exacerbation COPD Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-09-13

Study Completion Date

2023-10-08

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The pathophysiological characteristics of respiratory failure on exacerbation of chronic pulmonary obstructive disease are the rapid deteriorate of respiratory symptoms, combined with aggravated flow limitation, gas trapping, dynamic pulmonary hyperinflation (DPH), therefore the intrinsic PEEP (PEEPi) increases. It is worthwhile to explore bedside methods to quantify the changes in dynamic pulmonary hyperinflation to guide safe and effective mechanical ventilation in airflow limited patients.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effects of Non-invasive Ventilation on Respiratory Mechanics and NRD in Patients With Stable COPD

NCT03555097

Chronic Obstructive Pulmonary Disease

COMPLETED NA

The Relationship Between the Neural Drive and Intrinsic Positive End-expiratory Pressure

NCT04840628

Chronic Obstructive Pulmonary Disease

COMPLETED NA

End Tidal Carbon Dioxide Monitoring for Evaluating Changes of PaCO2 After Noninvasive Mechanical Ventilation in COPD

NCT01821365

COPD

UNKNOWN

A Study of Expiratory Pressure Modulation in Moderate to Severe COPD Patients - Phase 1b

NCT02585752

Chronic Obstructive Pulmonary Disease

TERMINATED NA

Effects of Inspiratory and Expiratory Pressure Training Methods in Patients With Chronic Obstructive Pulmonary Disease

NCT02326181

Chronic Obstructive Pulmonary Disease(COPD)

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The study hypothesizes that the electrical impedence tomography (EIT) measured the changes of end expiratory lung impedence (△EELI） could accurately predict the changes of end expiratory lung volume （△EELV） measured by passive expiratory in controlled mechanical ventilated exacerbation COPD patients. The research intended to conduct a research to explore the relationship between △EELI and △EELV induced by external PEEP changes in ventilated exacerbation COPD patients.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

COPD

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

PEEP titration for mechanical ventilated AECOPD patients

Pre- and post-self-controlled trials for invasive mechanical ventilated AECOPD patients during PEEP titration.

Group Type EXPERIMENTAL

the changes of end expiratory lung impedence

Intervention Type DIAGNOSTIC_TEST

the changes of end expiratory lung impedence measured by EIT

the changes of end expiratory lung volume

Intervention Type DIAGNOSTIC_TEST

the changes of end expiratory lung volume measured by apnea method

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

the changes of end expiratory lung impedence

the changes of end expiratory lung impedence measured by EIT

Intervention Type DIAGNOSTIC_TEST

the changes of end expiratory lung volume

the changes of end expiratory lung volume measured by apnea method

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

△EELI △EELV

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* 2022.7-2023.1 exacerbation COPD invasive ventilated patients admitted to the first affiliated Guangzhou medical university; 35 to 80 years old; in stable condition judged by clinicians

Exclusion Criteria

* SpO2\<88%; instable hemodynamic (MAP\<65mmHg；Norepinephrine\> 0.1ug/kg.min); pregnancy; 4 hour intravenous diuretics use before research; chest deformity and trauma, subpleural pulmonary bulla; implanted electronic devices(cardiac pacemaker, implantable cardioversion defibrillator,ect); tumour or other organ dysfunction; refuse to signature the informed consent

Minimum Eligible Age

35 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No