The Relationship Between the Neural Drive and Intrinsic Positive End-expiratory Pressure

NCT ID: NCT04840628

Last Updated: 2022-02-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-11-20

Study Completion Date

2021-07-03

Brief Summary

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To investigate the relation the nreural drive and intrinsic positive end-expiratory pressure(PEEPi) of the chronic obstructive pulmonary disease(COPD) patients with respiratory failure.In present study the PEEPi of COPD patients was increased by increasing the resistance of the respiratory system, the change of the neural drive was recorded.

Detailed Description

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To investigate the relation the nreural drive and intrinsic positive end-expiratory pressure(PEEPi) of the chronic obstructive pulmonary disease(COPD) patients with respiratory failure.The diaphragm electromyogram (EMGdi) represents the neural drive to the diaphragm.A multi-pair esophageal electrode catheter was used to record the EMGdi.The PEEPi was assessed by the by the balloon-catheter in the multi-pair esophageal electrode catheter. In present study the PEEPi of COPD patients was increased by increasing the resistance of the respiratory system, the change of the neural drive( EMGdi) was obtained from the a multi-pair esophageal electrode catheter All the signal recorded in the computer. The relation the nreural drive assessed by EMGdi and intrinsic positive end-expiratory pressure(PEEPi) would be analysed.

Conditions

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Chronic Obstructive Pulmonary Disease

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

the chronic obstructive pulmonary disease patients with respiratory failure
Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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neural respiratory drive

neural respiratory drive assessed by EMGdi recorded from a multipair esophageal electrode

Group Type EXPERIMENTAL

Resistance of the respiratory system

Intervention Type OTHER

increase the resistance of the respiratory system of the chronic obstructive pulmonary disease patients

Interventions

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Resistance of the respiratory system

increase the resistance of the respiratory system of the chronic obstructive pulmonary disease patients

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

chronic obstructive pulmonary disease patients with respiratory failure

Exclusion Criteria

1. Heart failure
2. cardiac dysrhythmia
3. Loss of consciousness
Minimum Eligible Age

50 Years

Maximum Eligible Age

70 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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The First Affiliated Hospital of Guangzhou Medical University

OTHER

Sponsor Role lead

Responsible Party

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Zhang Jianheng

Clinical Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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1State Key Laboratory of Respiratory Disease, National clinical research center for respiratory disease, Guangzhou Institute of respiratory health. 2The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China

Site Status

Countries

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China

Other Identifiers

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YLS2020(142)

Identifier Type: -

Identifier Source: org_study_id

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