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Airway Responsiveness in Patients With AECOPD Mechanical Ventilation by Inspiratory and Bronchial Dilation Testchronic Obstructive Pulmonary Disease

NCT ID: NCT02592122

Last Updated: 2015-10-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-10-31

Brief Summary

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In the patients with COPD mechanical ventilation, the bronchial dilatation is very common. However, the evaluation of the efficacy of the medical examination and other subjective indicators, such as doctors, depends on the doctor's experience; at present, there is no objective evaluation index. For patients with mechanical ventilation, the risk of cross infection can not only increase the risk of cross infection, but also increase the workload of clinical doctors and nurses. Therefore, this study proposes an objective evaluation method to evaluate the response of COPD patients to bronchial dilation. The hypothesis of this study can be used to guide the clinical medication through the test of the bronchus. If the patients with bronchial dilation test positive were used in the test, the patients were not used. In this evaluation method, the changes of airway resistance were measured by the accurate measurement of the patients with inhaled bronchial dilatation.

Detailed Description

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Conditions

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Lung Disease,Obstructive

Keywords

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Mechanical ventilation Chronic obstructive pulmonary disease Airway resistance Bronchial dilation test

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Atomization inhalation

First of all, investigators need to give patients to do the test, the result is more than 12% is positive group, less than 12% is negative group.Second, randomly selected into the atomization group

Group Type ACTIVE_COMPARATOR

Salbutamol Aerosol

Intervention Type DRUG

Without atomization inhalation

First of all, investigators need to give patients to do the test, the result is more than 12% is positive group, less than 12% is negative group.Secondly, the random selection is not the atomization group

Group Type ACTIVE_COMPARATOR

No drugs

Intervention Type DRUG

Interventions

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Salbutamol Aerosol

Intervention Type DRUG

No drugs

Intervention Type DRUG

Other Intervention Names

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Ammonium bromide bromide aerosol

Eligibility Criteria

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Inclusion Criteria

* Acute exacerbation of chronic obstructive pulmonary disease
* The mechanical ventilation time of the outdoor endotracheal intubation in the intensive care unit was less than 48 hours

Exclusion Criteria

* asthma
* has received tracheotomy
* long term mechanical ventilation (which has been accepted for more than 21 days).
* severe pneumonia
* Patients who cannot use a patient with bronchial dilation
* there's a taboo on the use of a sedative.
* refusal to participate in the study
* 48 hours to pull out the tube
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Primary-investigator,Bing Sun

UNKNOWN

Sponsor Role collaborator

snow

OTHER

Sponsor Role lead

Responsible Party

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snow

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Bing Sun

Role: PRINCIPAL_INVESTIGATOR

Beijing Chao Yang Hospital

Locations

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Department of respiratory and critical care medicine,Beijing Chao-yang Hospital

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Xue Wang, MB

Role: CONTACT

Phone: 0086-10-85231543

Email: [email protected]

Sun Bing, MD

Role: CONTACT

Phone: 86013911151075

Email: [email protected]

Facility Contacts

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Xue Wang, MB

Role: primary

Bing Sun, MD

Role: backup

References

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Li Y, Chen Y, Wang P. Application of impulse oscillometry and bronchial dilation test for analysis in patients with asthma and chronic obstructive pulmonary disease. Int J Clin Exp Med. 2015 Jan 15;8(1):1271-5. eCollection 2015.

Reference Type BACKGROUND
PMID: 25785124 (View on PubMed)

Other Identifiers

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2013-10-COPD

Identifier Type: -

Identifier Source: org_study_id