Ventilatory Adaptation to Concentric Versus Eccentric Exercise in Patients With Severe COPD
NCT ID: NCT03923660
Last Updated: 2019-04-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
20 participants
INTERVENTIONAL
2018-09-20
2019-12-31
Brief Summary
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However, the response to concentric exercise training is heterogeneous from one COPD patient to another. The inability of some COPD patients to achieve the exercise intensities required to stress limb muscles due to severe ventilatory limitation could partially explain their poor response to training.
Endurance exercise with eccentric muscle contractions could be an interesting alternative to concentric exercise because it produces greater muscle force through its lower metabolic cost. Eccentric exercise could allow patients with severe airflow limitation to perform prolonged exercise sessions with sufficient intensity to improve muscle function.
Nevertheless, a recent study performed in healthy young subjects reported that eccentric exercise induced a more hyperpneic breathing pattern (i.e., lower tidal volume and higher breathing frequency) that concentric for a given minute ventilation.
The main objective of CONvEX study is to compare ventilatory adaptation between two modalities of exercise performed on cycle ergometer (concentric versus eccentric) in severe COPD patients.
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Detailed Description
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However, the response to concentric exercise training is heterogeneous from one COPD patient to another. The inability of some COPD patients to achieve the exercise intensities required to stress limb muscles due to severe ventilatory limitation could partially explain their poor response to training.
Endurance exercise with eccentric muscle contractions could be an interesting alternative to concentric exercise because it produces greater muscle force through its lower metabolic cost. Eccentric exercise could allow patients with severe airflow limitation to perform prolonged exercise sessions with sufficient intensity to improve muscle function.
Nevertheless, a recent study performed in healthy young subjects reported that eccentric exercise induced a more hyperpneic breathing pattern (i.e., lower tidal volume and higher breathing frequency) that concentric for a given minute ventilation.
The main objective of CONvEX study is to compare ventilatory adaptation between two modalities of exercise performed on cycle ergometer (concentric versus eccentric) in severe COPD patients.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
NONE
Study Groups
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Concentric-eccentric
Concentric-eccentric
Incremental Concentric-eccentric exercise test
Patients will perform incremental exercise test on semi recumbent eccentric ergometer
Eccentric-concentric
Eccentric-concentric
Incremental Eccentric-concentric exercise test
Patients will perform incremental exercise test on semi recumbent concentric ergometer
Interventions
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Incremental Concentric-eccentric exercise test
Patients will perform incremental exercise test on semi recumbent eccentric ergometer
Incremental Eccentric-concentric exercise test
Patients will perform incremental exercise test on semi recumbent concentric ergometer
Eligibility Criteria
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Inclusion Criteria
* Informed consent
* Affiliation to a social security scheme
Exclusion Criteria
* Cardiovascular, neuromuscular or musculoskeletal disorders that can provide significant dyspnea or limit exercise
* Legal incapacity
* Low or no cooperation anticipated
40 Years
80 Years
ALL
No
Sponsors
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Centre Hospitalier Universitaire de Besancon
OTHER
Responsible Party
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Locations
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CHU de Besançon
Besançon, , France
Countries
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Other Identifiers
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P/2018/374
Identifier Type: -
Identifier Source: org_study_id
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