Study of Comprehensive ANd Multimodal Marker-based Cohort of Progressive Supranuclear Palsy(PSP)

NCT ID: NCT05579301

Last Updated: 2022-10-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

130 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-12-19

Study Completion Date

2025-02-28

Brief Summary

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The purpose of this cohort study is to develop a reliable biomarker in progressive nuclear palsy (PSP).

Detailed Description

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Progressive supranuclear palsy is a rapidly progressive neurodegenerative disease without a cure. Thus, the development of a biomarker that reflects and monitors disease severity in PSP is critical for early diagnosis and performing a successful clinical trial. Thus, we will prospectively recruit patients with PSP and collect comprehensive clinical, imaging and blood biomarkers at baseline with longitudinal follow-up for 1 year.

Conditions

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Progressive Supranuclear Palsy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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PSP patients

Patients with PSP according to the inclusion and exclusion criteria

No interventions assigned to this group

healthy controls

age-matched healthy controls according to the inclusion and exclusion criteria

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age 50 to 80 years, male or female
* Progressive supranuclear palsy (PSP) patients who are diagnosed as Probable, Possible or suggestive PSP with Movement Disorder society diagnostic criteria for PSP (Hoglinger et al., 2017)


* Age 50 to 80 years, male or female
* Those who agreed to participate in this study

Exclusion Criteria

* Subjects with clinically significant psychiatric illness
* Subjects with cancer or severe medical illness
* Lactating, pregnant, or possibly pregnant
* Subjects with small vessel disease (\> grade II) in brain MRI or other structural lesions by causes other than PSP
* Subjects with severe dementia patients (MMSE \< 19 or MoCA \<13 or General deterioration scale \>= 5)


* Those with a history of any neurological diseases
* Lactating, pregnant, or possibly pregnant
* Subjects with clinically significant psychiatric illness
* Subjects with cancer or severe medical illness
Minimum Eligible Age

50 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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SMG-SNU Boramae Medical Center

OTHER

Sponsor Role collaborator

Seoul National University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Jee-Young Lee

Clinical Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jee-Young Lee, M.D.

Role: PRINCIPAL_INVESTIGATOR

SMG-SNU Boramae Medical Center

Locations

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Seoul National University Boramae Hospital

Seoul, , South Korea

Site Status RECRUITING

Seoul National University Hospital

Seoul, , South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Jee-Young Lee, M.D.

Role: CONTACT

82-2-870-2476

Facility Contacts

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Jee-Young Lee, MD, PhD.

Role: primary

82-2-870-2476

Han-Joon Kim, MD, PhD

Role: primary

82-02-2072-1219

Other Identifiers

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SNUH_2022_0117

Identifier Type: -

Identifier Source: org_study_id

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