Biobank and Register of Patients With Agresive Tumors for Translational and Analytical Research

NCT ID: NCT05539677

Last Updated: 2024-05-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

1998-09-30

Study Completion Date

2030-12-31

Brief Summary

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The investigators will collect biosamples of patient blood and tumour tissue for further immunological analysis of blood cell subpopulations, immunosupressive factors concentration, HLA expression an lymphocytes and tumour tissue, and and cancer testis antigenes expression on tumour cells, as well as clinical data on patient's stage, therapy, response and demographics. Possible prognostic and predictive dynamic biomarkers will be discovered for individualisation of treatment strategies

Detailed Description

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Conditions

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Malignant Solid Tumors Primary Brain Tumor Melanoma Soft Tissue Sarcoma Colorectal Cancer Kidney Cancer Prostate Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Melanoma

No interventions assigned to this group

Soft tissue sarcoma

No interventions assigned to this group

Kidney cancer

No interventions assigned to this group

Primary brain tumors

No interventions assigned to this group

Malignant neoplasms

No interventions assigned to this group

Prostate cancer

No interventions assigned to this group

Colorectal cancer

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Signed inform consent
* Histolgically verified solid tumour
* Receiving systemic therapy for neoplasm
* Has archival tumour tissue
* Provide biosamples with living tumour tissue or blood samples for immunologic assessment

Exclusion Criteria

* Concurrent Lymphoprolipherative disorder
* Patients after stem cell or bone marrow thansplantation
* Incomplete informaton on previous cancer history or medical history
* Patients with known primary immunodeficiency
* Patients receiving immunosupressive therapy for concurrent illness
* Pregnant patients
Minimum Eligible Age

1 Year

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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N.N. Petrov National Medical Research Center of Oncology

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Irina Baldueva, MD, PhD, DSc

Role: STUDY_DIRECTOR

N.N. Petrov NMRC of Oncology

Locations

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N.N. Petrov NMRC of Oncology, Oncoimmunology dep.

Saint Petersburg, , Russia

Site Status RECRUITING

Countries

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Russia

Central Contacts

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Aleksei Novik, MD, PhD

Role: CONTACT

+78124399505

Tatiana Nekhaeva, MD, PhD

Role: CONTACT

+78124399514

Facility Contacts

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Aleksei Novik, MD, PhD

Role: primary

+78124399505

References

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Shendaleva N, Novik AV, Zozulya A, Nekhaeva TL, Semenova A, Teletaeva GM, et al. Impact of the azoximer bromide concomitant therapy on patient outcomes in patients with melanoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2021;39(15_suppl):e21574-e.

Reference Type RESULT

Novik AV, Shendaleva N, Zozulya A, Nekhaeva TL, Semenova A, Teletaeva GM, et al. Impact of the azoximer bromide concomitant therapy on outcomes in patients with soft tissue sarcoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2021;39(15_suppl):e23534-e.

Reference Type RESULT

Novik AV, Girdyuk DV, Nekhaeva TL, Emelyanova NV, Semenova A, Teletaeva GM, et al. Progression prediction model for solid tumors with clinical and immunological parameters. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2021;39(15_suppl):2539.

Reference Type RESULT

Other Identifiers

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AAAA-A18-118032890188-9

Identifier Type: -

Identifier Source: org_study_id

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