Different Concentrations of Dextrose Prolotherapy Treatment in Knee Osteoartritis
NCT ID: NCT05537077
Last Updated: 2022-09-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
128 participants
INTERVENTIONAL
2020-03-01
2021-03-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Group 1
%5 Dextrose prolotherapy, hotpack therapy and home based exercise program was applied to group 1.
Prolotherapy
DPT was applied as a total of 3 sessions at 0, 3 and 6 weeks. In each session, intra-articular 5 ml and periarticular 10 ml dextrose injections were administered to the knee. Periarticular injection was applied to 10 points as 1 ml in each region. The regions were determined as medial and lateral coronary ligaments, proximal and distal medial and lateral collateral ligaments, pes anserinus region, proximal and distal patellar tendon, quadriceps tendon attachment area.
Home based exercise program
Knee ROM, isometric and isotonic quadriceps strengthening exercises were given as 2 sets of 10 repetitions per day for 12 weeks.
Hotpack therapy
Hotpack treatment was applied for 20 minutes at 0, 3 and 6 weeks.
Group 2
%10 Dextrose prolotherapy, hotpack therapy and home based exercise program was applied to group 2.
Prolotherapy
DPT was applied as a total of 3 sessions at 0, 3 and 6 weeks. In each session, intra-articular 5 ml and periarticular 10 ml dextrose injections were administered to the knee. Periarticular injection was applied to 10 points as 1 ml in each region. The regions were determined as medial and lateral coronary ligaments, proximal and distal medial and lateral collateral ligaments, pes anserinus region, proximal and distal patellar tendon, quadriceps tendon attachment area.
Home based exercise program
Knee ROM, isometric and isotonic quadriceps strengthening exercises were given as 2 sets of 10 repetitions per day for 12 weeks.
Hotpack therapy
Hotpack treatment was applied for 20 minutes at 0, 3 and 6 weeks.
Group 3
%20 Dextrose prolotherapy, hotpack therapy and home based exercise program was applied to group 3.
Prolotherapy
DPT was applied as a total of 3 sessions at 0, 3 and 6 weeks. In each session, intra-articular 5 ml and periarticular 10 ml dextrose injections were administered to the knee. Periarticular injection was applied to 10 points as 1 ml in each region. The regions were determined as medial and lateral coronary ligaments, proximal and distal medial and lateral collateral ligaments, pes anserinus region, proximal and distal patellar tendon, quadriceps tendon attachment area.
Home based exercise program
Knee ROM, isometric and isotonic quadriceps strengthening exercises were given as 2 sets of 10 repetitions per day for 12 weeks.
Hotpack therapy
Hotpack treatment was applied for 20 minutes at 0, 3 and 6 weeks.
Group 4
Hotpack therapy and home based exercise program was applied to group 4.
Home based exercise program
Knee ROM, isometric and isotonic quadriceps strengthening exercises were given as 2 sets of 10 repetitions per day for 12 weeks.
Hotpack therapy
Hotpack treatment was applied for 20 minutes at 0, 3 and 6 weeks.
Interventions
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Prolotherapy
DPT was applied as a total of 3 sessions at 0, 3 and 6 weeks. In each session, intra-articular 5 ml and periarticular 10 ml dextrose injections were administered to the knee. Periarticular injection was applied to 10 points as 1 ml in each region. The regions were determined as medial and lateral coronary ligaments, proximal and distal medial and lateral collateral ligaments, pes anserinus region, proximal and distal patellar tendon, quadriceps tendon attachment area.
Home based exercise program
Knee ROM, isometric and isotonic quadriceps strengthening exercises were given as 2 sets of 10 repetitions per day for 12 weeks.
Hotpack therapy
Hotpack treatment was applied for 20 minutes at 0, 3 and 6 weeks.
Eligibility Criteria
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Inclusion Criteria
* Knee pain for more than three months,
* Diagnosed with primary knee OA according to ACR clinical/radiological diagnostic criteria and Kellgren-Lawrence stage II-III.
Exclusion Criteria
* Rheumatological diseases, systemic infection, and malignancy
* Pregnancy or breastfeeding
* Taking a nonsteroidal anti-inflammatory drug (NSAID) in the last week, taking steroid drugs in the last month
* Undergoing anticoagulant or immunosuppressive therapy
* Knee injection in the last 6 months
40 Years
70 Years
ALL
No
Sponsors
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Turkish League Against Rheumatism
OTHER
Responsible Party
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Muhammet Uğur ÖZTÜRK
Medical Doctor
Locations
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Ataturk University Faculty of Medicine
Erzurum, , Turkey (Türkiye)
Countries
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References
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Wee TC, Neo EJR, Tan YL. Dextrose prolotherapy in knee osteoarthritis: A systematic review and meta-analysis. J Clin Orthop Trauma. 2021 May 20;19:108-117. doi: 10.1016/j.jcot.2021.05.015. eCollection 2021 Aug.
Sert AT, Sen EI, Esmaeilzadeh S, Ozcan E. The Effects of Dextrose Prolotherapy in Symptomatic Knee Osteoarthritis: A Randomized Controlled Study. J Altern Complement Med. 2020 May;26(5):409-417. doi: 10.1089/acm.2019.0335. Epub 2020 Mar 30.
Ozturk MU, Baygutalp F. A comparative analysis of prolotherapy efficacy in patients with knee osteoarthritis across varied dextrose concentrations. Clin Rheumatol. 2023 Dec;42(12):3321-3331. doi: 10.1007/s10067-023-06723-4. Epub 2023 Aug 4.
Other Identifiers
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TRASD-MUO-TEZ
Identifier Type: -
Identifier Source: org_study_id
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