Effects of Platelet-Rich Plasma and Ozone Therapy in Knee Osteoarthritis

NCT ID: NCT06631456

Last Updated: 2024-10-08

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 54 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-08-01
• Study Completion Date: 2024-10-01

Brief Summary

Knee osteoarthritis can frequently occur with advancing age. In cases of pain that persists despite hot/cold applications, drug therapy and exercise, intra-articular injections are considered. In advanced-stage gonarthrosis, steroid injections may respond. However, in mild and moderate knee arthritis, regenerative methods come to the forefront because the joint cartilage is still partially/completely intact. PRP and ozone therapy are frequently applied intra-articular treatments. This study will compare the effects of both injection methods on clinical outcomes.

Detailed Description

Knee osteoarthritis is a common arthrosis that can be encountered frequently with increasing life expectancy. In mild-moderate stages, hot/cold applications, drug treatments and exercise applications are usually applied, while in those who do not respond, physical therapy or intra-articular injection treatments are applied. This retrospective study aims to examine the effects of intra-articular Platelet Rich Plasma (PRP) and ozone therapy on pain, functionality and quality of life in patients with Stage 2-3 gonarthrosis according to the Kelgren-Lawrence (KL) Classification.

Conditions

Knee Osteoarthritis

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: OTHER

Study Groups

PRP group

Patients who received intra-articular PRP due to gonarthrosis

PRP injection

Intervention Type: OTHER

A total of 3 doses of intra-articular PRP were applied to the symptomatic knees of the patients under ultrasound guidance, once a week.

Ozone group

Patients who received intra-articular ozone therapy due to gonarthrosis

Ozone therapy

Intervention Type: OTHER

A total of 3 doses of intra-articular ozone therapy were applied to the symptomatic knees of the patients under ultrasound guidance, once a week.

Interventions

PRP injection

A total of 3 doses of intra-articular PRP were applied to the symptomatic knees of the patients under ultrasound guidance, once a week.

Intervention Type: OTHER

Ozone therapy

A total of 3 doses of intra-articular ozone therapy were applied to the symptomatic knees of the patients under ultrasound guidance, once a week.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• 30-70 years old, Stage 2-3 gonarthrosis according to KL
• Voluntariness to participate in the study

Exclusion Criteria

• Cognitive dysfunction
• General medical condition is not suitable for injections and evaluations
• History of knee injections in the last 3 months
• History of previous knee surgery
• Bleeding disorders or those taking medications that may cause bleeding disorders after injections

• Minimum Eligible Age: 30 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Sisli Hamidiye Etfal Training and Research Hospital

OTHER

Sponsor Role: lead

Responsible Party

Selda Çiftci

Medical Doctor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Banu Kuran, Professor

Role: STUDY_DIRECTOR

Şişli Hamidiye Etfal Training and Research Hospital

Locations

Şişli Hamidiye Etfal Training and Research Hospital, İstanbul

Istanbul, , Turkey (Türkiye)

Countries

Turkey (Türkiye)

Other Identifiers

09/07/2024-4460

Identifier Type: -

Identifier Source: org_study_id