Investigation of the Effects of Physiotherapy in Patients With Platelet Rich Plasma (PRP) Applied Knee Osteoarthritis

NCT ID: NCT04387396

Last Updated: 2021-02-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

26 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-08-01

Study Completion Date

2020-12-29

Brief Summary

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This study evaluates effects of PRP and physiotherapy on pain, physical function and quality of life in patients with knee osteoarthritis.

Detailed Description

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PRP has been reported to have a low to moderate level of evidence in patients with knee osteoarthritis (OA) in reducing pain and improving function. Similarly, in individuals with knee osteoarthritis, exercise has been reported to be effective in reducing the pain and improving physical function of the knee OA patient in the short term, and may be even more effective with individual exercise programs. However, there is no study examining the effect of PRP and exercise together. PRP and exercise can be more effective together. The aim of our study was to investigate the effects of physiotherapy on pain, physical function and quality of life in patients with knee OA who underwent PRP injection.

Conditions

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Knee Osteoarthritis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Physiotherapy

Exercise intervention will be applied to this arm.

Group Type EXPERIMENTAL

Exercise

Intervention Type OTHER

Exercise specific to knee osteoarthritis.

Control

No intervention will be made to this arm, only evaluations will be made.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Exercise

Exercise specific to knee osteoarthritis.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Grade 2-3 according to Kellgren Lawrence osteoarthritis classification,
* Patients with knee osteoarthritis who underwent PRP injection at least three days ago,
* Being volunteer

Exclusion Criteria

* Any intra-articular application and / or physiotherapy and rehabilitation in the last 6 months,
* Have any other orthopedic problems involving the lower extremities
* Having cognitive problems,
* Having additional neurological, rheumatologic and / or oncological problems
Minimum Eligible Age

45 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Hacettepe University

OTHER

Sponsor Role lead

Responsible Party

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Sibel Bozgeyik

PT, PhD(c)

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Feza Korkusuz, Prof.

Role: PRINCIPAL_INVESTIGATOR

Hacettepe University

Locations

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Hacettepe University

Ankara, Samanpazari, Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Arthritis Rheum. 2000 Sep;43(9):1905-15. doi: 10.1002/1529-0131(200009)43:93.0.CO;2-P. No abstract available.

Reference Type BACKGROUND
PMID: 11014340 (View on PubMed)

MILLER JH, WHITE J, NORTON TH. The value of intra-articular injections in osteoarthritis of the knee. J Bone Joint Surg Br. 1958 Nov;40-B(4):636-43. doi: 10.1302/0301-620X.40B4.636. No abstract available.

Reference Type BACKGROUND
PMID: 13610976 (View on PubMed)

Bennell KL, Hunt MA, Wrigley TV, Lim BW, Hinman RS. Role of muscle in the genesis and management of knee osteoarthritis. Rheum Dis Clin North Am. 2008 Aug;34(3):731-54. doi: 10.1016/j.rdc.2008.05.005.

Reference Type BACKGROUND
PMID: 18687280 (View on PubMed)

Laudy AB, Bakker EW, Rekers M, Moen MH. Efficacy of platelet-rich plasma injections in osteoarthritis of the knee: a systematic review and meta-analysis. Br J Sports Med. 2015 May;49(10):657-72. doi: 10.1136/bjsports-2014-094036. Epub 2014 Nov 21.

Reference Type BACKGROUND
PMID: 25416198 (View on PubMed)

Chang TF, Liou TH, Chen CH, Huang YC, Chang KH. Effects of elastic-band exercise on lower-extremity function among female patients with osteoarthritis of the knee. Disabil Rehabil. 2012;34(20):1727-35. doi: 10.3109/09638288.2012.660598. Epub 2012 Mar 8.

Reference Type BACKGROUND
PMID: 22397710 (View on PubMed)

Provided Documents

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Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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KA-180151

Identifier Type: -

Identifier Source: org_study_id

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