Myotonometer Intra- and Inter Examiner Reliability on Spinal Muscular Atrophy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-08-26

Study Completion Date

2022-10-15

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The primary aim of the study was to measure the intra-rater and inter-rater reliability of MyotonPRO in measuring postural muscle tone and mechanical properties in individuals with spinal muscular atrophy (SMA). The secondary aim is to question the existence of a relationship between the functional levels of individuals with SMA and their muscle tone and biomechanical properties. It is assumed that the outputs to be obtained from this research will form the norm data for moyotonometer evaluation in children with SMA.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Myotonia and Muscle Stiffness in NMD

NCT04411732

Neuromuscular Disorders

COMPLETED

Evaluation of Therapeutic Response in Spinal Muscular Atrophy Using Multispectral Optoacoustic Tomography (MSOT) and Magnetic Resonance Imaging (MRI)

NCT04262570

Muscular Diseases Spinal Muscular Atrophy

UNKNOWN NA

Ultrasonographic Evaluation of Abdominal Muscle Thickness Symmetry and Correlation With Pulmonary Function

NCT04567914

Muscle Physiology Adolescent Idiopathic Scoliosis

COMPLETED

Neurophysiological Evaluation of Muscle Tone

NCT05070780

Muscle Tone Abnormalities Rigidity, Muscle Spasticity, Muscle

UNKNOWN

Stroke and Assessment of Muscle Tone

NCT03814460

Stroke Muscle Tone Abnormalities Pain +1 more

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

It seems to be important to examine peripheral changes in the pathogenesis of SMA. Although it shows that the target center in SMA is alpha motor neurons located in the anterior horn of the spinal cord, considering the interaction network of interneurons, cerebellum, neuromuscular junction, gamma-alpha motor neuron pool, descending and ascending pathways, and reflex arc, it has potential to be investigated in individuals with SMA. This suggests that it may have important consequences for peripheral mechanisms. It may be important to examine muscle mechanical properties to reveal any potential correlations between SMA types and disease progression. In addition, moyotonometer results can be a key evaluation method in examining treatment efficacy, diagnosis and disease course. However, in order for these activities to be observed with myotonometer, first of all, the reliability of its use in individuals with SMA should be questioned.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Muscle Tone Poor Spinal Muscular Atrophy

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Children with Spinal Muscular Atrophy

The patients were included if they were between 0 to 4 yeats, with a diagnosis of Spinal Muscular Atrophy.

MyotonPRO

Intervention Type DIAGNOSTIC_TEST

Evaluation of biomechanics and viscoelastic properties of posture muscle in children with Spinal Muscular Atrophy.

The biomechanical and viscoelastic properties of the posture muscle in children with Spinal Muscular Atrophy. will be measured with the MyotonPRO device.

Healthy children

The healthy age-matched control group was included.

MyotonPRO

Intervention Type DIAGNOSTIC_TEST

Evaluation of biomechanics and viscoelastic properties of posture muscle in children with Spinal Muscular Atrophy.

The biomechanical and viscoelastic properties of the posture muscle in children with Spinal Muscular Atrophy. will be measured with the MyotonPRO device.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

MyotonPRO

Evaluation of biomechanics and viscoelastic properties of posture muscle in children with Spinal Muscular Atrophy.

The biomechanical and viscoelastic properties of the posture muscle in children with Spinal Muscular Atrophy. will be measured with the MyotonPRO device.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Between 0-4 years old
* Diagnosed with spinal muscular atrophy (SMA)
* Children who continue their medical treatment at home and are not in intensive care
* Children of families who agreed to participate in the study and approved the informed consent form.