The Impact of Intravenous Vitamin C Combined With Nerve Blocks on Postoperative Pain and Recovery After Total Knee Arthroplasty
NCT ID: NCT05514197
Last Updated: 2025-11-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
73 participants
INTERVENTIONAL
2022-11-02
2024-01-11
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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Vitamin C arm
Intravenous loading of 100mg/kg ascorbic acid before induction, Maximus 10g
Ascorbic acid 100mg/kg, Maximus 10g
Intravenous loading of 100mg/kg ascorbic acid with normal saline, totally 100ml Completed before induction
Control arm
Intravenous loading of the same volume Normal saline as experimental arm
Control Rx
Intravenous loading 100ml normal saline
Interventions
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Ascorbic acid 100mg/kg, Maximus 10g
Intravenous loading of 100mg/kg ascorbic acid with normal saline, totally 100ml Completed before induction
Control Rx
Intravenous loading 100ml normal saline
Eligibility Criteria
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Inclusion Criteria
2. Patients scheduled for total knee arthroplasty
3. Patients aged ranging from 50 to 80 years old
Exclusion Criteria
2. Allergy or intolerance to one of the study medications
3. Coagulopathy
4. Having lower limbs neuropathy
5. End-organ failure (CKD stage IV or V, NYHA III or IV)
6. BMI \> 35
7. Chronic opioid use (\>3 months) or drug abuser
8. Difficulty in communication (Impaired mental status)
9. Hyperuricemia or Glucose-6-phosphate dehydrogenase deficiency patient
50 Years
80 Years
ALL
No
Sponsors
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Chimei Medical Center
OTHER
Responsible Party
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Principal Investigators
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Jen-Yin Chen
Role: STUDY_DIRECTOR
Department of Anesthesiology, Chimei Medical Center
Locations
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Chi Mei Medical Center
Tainan, Tainan City, Taiwan
Countries
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Other Identifiers
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CMMC11104/016
Identifier Type: -
Identifier Source: org_study_id
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