Adductor Canal Nerve Block Following Total Knee Arthroplasty

NCT ID: NCT01939379

Last Updated: 2021-04-20

Basic Information

• Recruitment Status: WITHDRAWN
• Clinical Phase: NA
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-09-30
• Study Completion Date: 2017-07-25

Brief Summary

The purpose of this study is that an adductor canal nerve block (putting numbing medicine near the nerve) has been shown to produce excellent pain relief with less pain medication use after knee replacement surgery.The investigators will be comparing the amount of pain relief following knee replacement surgery when you have a nerve block in place. There will be approximately 66 subjects participating in this study. After surgery subjects will receive numbing medication every 6 hours for 48 hours. Subjects will also receive a morphine PCA (patient controlled analgesia) after surgery and pain medication by mouth every 4 hours around the clock with the option to receive more pain medication if needed. Subjects will participate in the study up to 3 days.

Conditions

Post-op Pain

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

15ml ropivacaine

Depending on what dose of ropivacaine the subject is randomized to he/she could receive the 15ml dose injected into the catheter every 6 hours

Group Type: ACTIVE_COMPARATOR

Morphine PCA started at the end of surgery, 1 Percocet 1/325mg every 4 hours; may receive a second Percocet if needed.

Intervention Type: DRUG

30ml ropivacaine

If the subject is randomized to 30ml ropivacaine he/she will be injected through the catheter every 6 hours.

Group Type: ACTIVE_COMPARATOR

For the 30ml ropivacaine the intervention would be the subject can request extra pain medication which would be Percocet and/or morphine PCA.

Intervention Type: DRUG

Interventions

Morphine PCA started at the end of surgery, 1 Percocet 1/325mg every 4 hours; may receive a second Percocet if needed.

Intervention Type: DRUG

For the 30ml ropivacaine the intervention would be the subject can request extra pain medication which would be Percocet and/or morphine PCA.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Is the subject undergoing primary unilateral total knee arthroplasty?

2. Is the subject 18 to 99 years of age?

3. Is the subject ASA class 1, 2, or 3?

4. Does the subject have a BMI less than 35?

5. Can the subject consent in the English language?

Exclusion Criteria

1. Does subject have an allergy to drugs used in this study;

2. Does subject have a daily intake of opiate medications that are considered stronger than hydrocodone?

3. Does subject have a history of alcohol or drug abuse

4. Has subject had a previous total knee arthroplasty?

5. Has subject had any neurologic deficits in the lower extremity being studied?

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 99 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Loma Linda University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Loma Linda University Medical Center East Campus Hospital

Loma Linda, California, United States

Countries

United States

Other Identifiers

5130183

Identifier Type: -

Identifier Source: org_study_id