Blood Purification Therapy With Dual-cannula in Jugular-femoral Venous

NCT ID: NCT05510713

Last Updated: 2022-08-22

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 50 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-09-01
• Study Completion Date: 2024-10-01

Brief Summary

Acute kidney failure (AKI) is one of the most important causes of morbidity and mortality for critical ill patients. The use of blood purification treatment such as renal replacement therapy (CRRT) and plasma exchange has gradually developed into an effective treatment. However, the efficiency of blood purification may be affected by the recirculation of dual-lumen venous catheter for some special patients including patients with vena cava reflux disorder from massive occupations or ascites. For extreme cases like patients with vena cava disconnection or severe obstruction, the traditional blood purification treatment cannot work effectively. Thus, we used the dual-cannula in jugular-femoral venous blood purification therapy in the following two patients and found that it can improve the perfusion of systemic circulation and the prognosis of patients

Conditions

Blood Purification; Dual-cannula; Vena Cava Disconnection

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

the treatment-as-usual group

we used the single-cannula in femoral venous blood purification therapy in the following patients with vena cava disconnection or severe obstruction

Group Type: NO_INTERVENTION

No interventions assigned to this group

intervention group

we used the dual-cannula in jugular-femoral venous blood purification therapy in the following patients with vena cava disconnection or severe obstruction

Group Type: EXPERIMENTAL

Hemodialysis Catheter

Intervention Type: DEVICE

We add a dialysis catheter to the patient, i.e., replace single-cannula in femoral venous with dual-cannula in jugular-femoral venous

Interventions

Hemodialysis Catheter

We add a dialysis catheter to the patient, i.e., replace single-cannula in femoral venous with dual-cannula in jugular-femoral venous

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• 1. patients requiring haemodilution therapy for various reasons (acute renal failure, acute liver failure, etc.)
• 2. presence of superior vena cava and/or inferior vena cava reflux disorders
• 3. age greater than 18 years

Exclusion Criteria

• 1. Inability to establish suitable vascular access
• 2. Pregnant women
• 3. Not agreeing to active life support treatment
• 4. Severe active bleeding

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Shanghai Zhongshan Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Minjie Ju, PHD

Role: STUDY_DIRECTOR

Shanghai Zhongshan Hospital

Central Contacts

Zhunyong Gu

Role: CONTACT

gu.zhunyong@zs-hospital.sh.cn

8613918677995

Other Identifiers

jv-fv-RRT

Identifier Type: -

Identifier Source: org_study_id