Neurological Impairment in a Young Population Exposed to Recreational Nitrous Oxide
NCT ID: NCT05469321
Last Updated: 2024-01-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
20 participants
OBSERVATIONAL
2022-08-22
2024-12-31
Brief Summary
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It can be responsible in case of prolonged use and overdose of a vitamin B12 deficiency with possible neuropsychiatric complications: sensitivomotor neuropathy, myelopathy, behavioral and cognitive disorders of acute or sub-acute installation.
N2O inhibits the activitý of methionine synthase, decreases the activitý of methylmalonyl-CoA mutase leading to vitamin B12 deficiency but in addition to the interference with vitamin B12 metabolism there seems to be a direct toxicity of N20.
Myelin alteration was the typical electromyography finding but new axonal profiles were also described. Since myelopathy affects both the posterior and lateral cords, combined spinal cord sclerosis is the most common location of injury associated with N2O intoxication.
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Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Patients
patients presenting to the CHU of Nîmes for an acute or subacute neurological picture after having consumed N2O.
None, pure observationnal study
None, pure observational study following the usual management of the patients
Interventions
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None, pure observationnal study
None, pure observational study following the usual management of the patients
Eligibility Criteria
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Inclusion Criteria
\-
15 Years
ALL
No
Sponsors
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Centre Hospitalier Universitaire de Nīmes
OTHER
Responsible Party
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Principal Investigators
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Anissa MEGZARI
Role: STUDY_DIRECTOR
Centre Hospitalier Universitaire de Nīmes
Locations
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CHU de Nîmes
Nîmes, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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Local/2022/II-03
Identifier Type: -
Identifier Source: org_study_id
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