Effect of Nitrous Oxide on Cisatracurium Infusion Demands
NCT ID: NCT01152905
Last Updated: 2010-06-29
Study Results
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Basic Information
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COMPLETED
70 participants
OBSERVATIONAL
2007-04-30
2008-07-31
Brief Summary
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Methods: 70 ASA physical status I-III patients aged 18-75 years were enrolled in this randomized trial. The patients were undergoing elective surgery requiring general anesthesia with a duration of at least 90 minutes. Patients were randomized to receive propofol and remifentanil by target controlled infusion in combination with either a mixture of oxygen and nitrous oxide (Nitrous oxide/TIVA group) or oxygen in air (Air/TIVA group). A 0.1 mg/kg initial bolus of cisatracurium was administered before tracheal intubation, followed by a closed-loop computer controlled infusion of cisatracurium to produce and maintain a 90% neuromuscular block. Cumulative dose requirements of cisatracurium during the 90-min study period after bolus administration were measured and the asymptotic steady state rate of infusion to produce a constant 90% block was determined by applying nonlinear curve fitting to the data on the cumulative dose requirement during the study period.
Results: Controller performance, i.e. the ability of the controller to maintain neuromuscular block constant at the setpoint and patient characteristics were similar in both groups. The administration of nitrous oxide did not affect cisatracurium infusion requirements. The mean steady-state rates of infusion were 0.072 +/- 0.018 and 0.066 +/- 0.017 mg \* kg-1 \* h-1 in Air/TIVA and Nitrous oxide/TIVA groups, respectively.
Conclusions: Nitrous oxide does not affect the infusion requirements of cisatracurium.
Detailed Description
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Conditions
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Keywords
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Air/TIVA group
The patients received during the anesthesia a mixture of air with 30% oxygen All patients received total intravenous anesthesia (TIVA) using target controlled infusion of propofol and remifentanil.
No interventions assigned to this group
Nitrous oxide/TIVA group
The patients received nitrous oxide with 30% oxygen.All patients received total intravenous anesthesia (TIVA) using target controlled infusion of propofol and remifentanil.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Hepatic or cardiac disease
18 Years
75 Years
ALL
No
Sponsors
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Turku University Hospital
OTHER_GOV
Responsible Party
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Dept. of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine
Locations
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Department of Anesthesiology, Intensive Care, Emergency Care and Pain Medicine, Turku University Hospital
Turku, , Finland
Countries
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References
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Illman HL, Antila HM, Olkkola KT. Effect of nitrous oxide on cisatracurium infusion demands: a randomized controlled trial. BMC Anesthesiol. 2010 Aug 18;10:14. doi: 10.1186/1471-2253-10-14.
Other Identifiers
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225/2006
Identifier Type: -
Identifier Source: org_study_id