Disorders of Sex Development (DSD) 46.XY in Three Siblings

NCT ID: NCT05449080

Last Updated: 2022-07-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

3 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-10-01

Study Completion Date

2021-12-31

Brief Summary

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This is a case series of three siblings with DSD 46,XY with relevant discussion

Detailed Description

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This is a case series of three sisters with DSD 46 X,Y. Three sisters, aged nineteen, seventeen, and fifteen years old came with an identical complaint of late menarche. Physical examinations, lab results and karyotypes were performed.

Conditions

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Genotype

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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Cases

subjects with type 2 5-alpha reductase deficiency

Karyotype

Intervention Type DIAGNOSTIC_TEST

Patients were subjected to karyotype to determine their genotype

Interventions

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Karyotype

Patients were subjected to karyotype to determine their genotype

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* 3 female siblings with identical complaints of no menarche

Exclusion Criteria

* patients outside this family.
Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Universitas Padjadjaran

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Department of Obstetrics and Gynecology, Universitas Padjadjaran

Bandung, , Indonesia

Site Status

Countries

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Indonesia

References

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Marzuki NS, Idris FP, Kartapradja HD, Harahap AR, Batubara JRL. Characterising SRD5A2 Gene Variants in 37 Indonesian Patients with 5-Alpha-Reductase Type 2 Deficiency. Int J Endocrinol. 2019 Dec 1;2019:7676341. doi: 10.1155/2019/7676341. eCollection 2019.

Reference Type BACKGROUND
PMID: 31885560 (View on PubMed)

Walter KN, Kienzle FB, Frankenschmidt A, Hiort O, Wudy SA, van der Werf-Grohmann N, Superti-Furga A, Schwab KO. Difficulties in diagnosis and treatment of 5alpha-reductase type 2 deficiency in a newborn with 46,XY DSD. Horm Res Paediatr. 2010;74(1):67-71. doi: 10.1159/000313372. Epub 2010 Apr 16.

Reference Type RESULT
PMID: 20395661 (View on PubMed)

Other Identifiers

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OBGY-202206.03

Identifier Type: -

Identifier Source: org_study_id

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