Pattern of Growth and Characteristics of Down Syndrome Pediatrics Patients

NCT ID: NCT05056285

Last Updated: 2021-09-24

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 50 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-10-01
• Study Completion Date: 2022-04-30

Brief Summary

Down syndrome or Down's syndrome (DS), also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. It is usually associated with physical growth delays, mild to moderate intellectual disability, and characteristic facial features. The parents of the affected individual are usually genetically normal. The probability increases from less than 0.1% in 20-year-old mothers to 3% in those of age 45 .

Detailed Description

People with DS may have some or all of these physical characteristics: a small chin, slanted eyes, poor muscle tone, a flat nasal bridge, a single crease of the palm, and a protruding tongue due to a small mouth and relatively large tongue. Other features include: a flat and wide face, a short neck, excessive joint flexibility, extra space between big toe and second toe, abnormal patterns on the fingertips and short fingers. Short stature is a characteristic feature of DS. Growth retardation of DS individuals starts prenatally. After birth, the growth velocity is most reduced between 6 months to 3 years . Growth charts specific for children with DS are important tools for routine medical follow-up, as well as early identification of pathological causes of growth retardation, and monitoring of growth promoting treatments. Growth charts for DS are available from different countries, for example, Italy, USA, Denmark, Sweden, Portugal, France, UK and Ireland and Saudi Arabia .

Conditions

Growth Disorders

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: OTHER

Study Groups

Down syndrome less than four years Group

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• All Down syndrome children attending Assuit university less than four years with or without cardiovascular.

Exclusion Criteria

• Any Down syndrome child more than four years.

• Maximum Eligible Age: 4 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Amira Gaber Osman

Amira Gaber Osman

Responsibility Role: PRINCIPAL_INVESTIGATOR

Central Contacts

Dalia Galal Mahran, Professor

Role: CONTACT

daliaym2001@yahoo.com

01007120821

Hekma Saad Farghaly, Professor

Role: CONTACT

hekmafarghly73@gmail.com

01091251040

References

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Reference Type: BACKGROUND

PMID: 6225471 (View on PubMed)

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Reference Type: BACKGROUND

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Reference Type: RESULT

PMID: 19526251 (View on PubMed)

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Reference Type: RESULT

PMID: 20632187 (View on PubMed)

Other Identifiers

PogacoDsppaAuch

Identifier Type: -

Identifier Source: org_study_id