Water Drinking Test Study and Disc Hemorrhages in Normal Tension Glaucoma
NCT ID: NCT05075369
Last Updated: 2021-10-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
20 participants
INTERVENTIONAL
2021-10-31
2022-04-30
Brief Summary
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Patients with normal tension glaucoma and a disc hemorrhage will be recruited to undergo a water drinking test prior to any change in their treatment.
Detailed Description
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Upon arrival the patients baseline intraocular pressure (IOP) will be measured, then shortly afterwards the patient will drink 800 ml of water in a period of 5 minutes. Immediately after the water ingestion has finished a second IOP will be measured, followed by IOP measurements every 15 minutes for 60 minutes with a Goldman applanation tonometer by the same examiner. All of these measurements will be collected in a data sheet for the WTD. A total of 60 minutes would be the duration of the activity.
Conditions
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Study Design
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NON_RANDOMIZED
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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baseline Intraocular pressure
The participants will have their intraocular pressure measured with Goldmann Application Tonometry immediately prior to beginning the water drinking test.
No interventions assigned to this group
Change in Intraocular pressure with Water drinking test
The participants will undergo the water drinking test as previously described, i.e. after drinking 800 mls of water over a 5 minute period, the intraocular pressure will be measured immediately after completion of ingestion, followed by intraocular pressure measurements every 15 minutes for 60 minutes, using etc Goldmann apllantion tonometer.
water drinking test
Water drinking test-glaucoma diagnostic test - marker for outflow facility reserve to detect IOP instability when the body ingests 800 ml of water within a 5 minute period of time
Interventions
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water drinking test
Water drinking test-glaucoma diagnostic test - marker for outflow facility reserve to detect IOP instability when the body ingests 800 ml of water within a 5 minute period of time
Eligibility Criteria
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Inclusion Criteria
* Clinical diagnosis of a disc hemorrhage diagnosed by a fellowship trained glaucoma specialist,
* Must be able to swallow water
* Must be able to be positioned to allow accurate measurement of the Intraocular pressure with a slit lamp mounted Goldmann applanation tonometer
* Must have a smooth corneal surface to allow for accurate Goldmann application tonometry measurement
* Outpatient
* A sufficient level of education to understand study procedures and be able to communicate with site personnel
Exclusion Criteria
* Active ocular infection,
* Pregnancy,
* Cardiac or renal diseases, history of urinary retention,
* Corneal abnormalities preventing reliable IOP measurements,
* Previous trabeculectomy or glaucoma shunt surgery,
* Previous laser iridotomy,
* Cognitive impairment or language barrier preventing ability to provide an informed consent.
18 Years
90 Years
ALL
No
Sponsors
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University of Manitoba
OTHER
Responsible Party
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Lisa Gould
Lisa Gould Associate Professor
Principal Investigators
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Lisa Gould, MD FRCS
Role: PRINCIPAL_INVESTIGATOR
University of Manitoba
Central Contacts
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References
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Susanna R Jr, Vessani RM, Sakata L, Zacarias LC, Hatanaka M. The relation between intraocular pressure peak in the water drinking test and visual field progression in glaucoma. Br J Ophthalmol. 2005 Oct;89(10):1298-301. doi: 10.1136/bjo.2005.070649.
Susanna R Jr, Clement C, Goldberg I, Hatanaka M. Applications of the water drinking test in glaucoma management. Clin Exp Ophthalmol. 2017 Aug;45(6):625-631. doi: 10.1111/ceo.12925. Epub 2017 Mar 9.
Ishida K, Yamamoto T, Sugiyama K, Kitazawa Y. Disk hemorrhage is a significantly negative prognostic factor in normal-tension glaucoma. Am J Ophthalmol. 2000 Jun;129(6):707-14. doi: 10.1016/s0002-9394(00)00441-4.
Other Identifiers
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Karla Zuniga
Identifier Type: OTHER
Identifier Source: secondary_id
B2021 060
Identifier Type: -
Identifier Source: org_study_id