New Quantitive MRI Parameters in Assessing Kidneys of Autosomal Dominant Polycystic Kidney Disease

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-12-31

Study Completion Date

2016-03-31

Brief Summary

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The purpose of this study is to establish normal Magnetic Resonance quantitative values (tissues stiffness, Apparent Diffusion Coefficient values and Blood Oxygen Level Determination values for both renal cortex and medullary tissues and total renal blood flow) for young Autosomal Dominant Polycystic Kidney Disease patients with normal renal function, and normal young adult controls without Autosomal Dominant Polycystic Kidney Disease and normal renal function.

Hypothesis: Newer Magnetic Resonance quantitative imaging parameters (tissue stiffness, Apparent Diffusion Coefficient, Blood Oxygen Level Determination levels, Magnetization Transfer and renal blood flow) will have different values in young adult ADPKD patients as compared to normal volunteers.

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Detailed Description

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Conditions

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Autosomal Dominant Polycystic Kidney Disease Kidney Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Male and female subjects between 18-30 years of age
* Diagnosis of ADPKD
* Glomerular Filtration Rate (GFR) of \> or = to 60 mL/min (Chronic Kidney Disease-Epidemiology Collaboration equation)
* Ability to provide written, informed consent

* Male and female subjects between 18-30 years of age
* Glomerular Filtration Rate (GFR) of \> or = to 60 mL/min (Chronic Kidney Disease-Epidemiology Collaboration equation)
* Ability to provide written, informed consent

Exclusion Criteria

* Clinically significant concomitant systemic disease
* Subjects with Diabetes Mellitus
* Urinary protein excretion
* Abnormal urinalysis suggestive of concomitant glomerular disease
* Subjects having contraindications to, or interference with MRI assessments
* Subjects with supine blood pressure higher than 140/90 mm Hg or taking blood pressure medications

* Previous personal or family history of kidney disease
* Clinically significant concomitant systemic disease
* Subjects with Diabetes Mellitus
* Urinary protein excretion
* Abnormal urinalysis suggestive of concomitant glomerular disease
* Subjects having contraindications to, or interference with MRI assessments
* Subjects with supine blood pressure higher than 140/90 mm Hg or taking blood pressure medications

Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes