Prevention of Incontinence-associated Dermatitis

NCT ID: NCT05403762

Last Updated: 2024-10-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

210 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-08-19

Study Completion Date

2025-05-31

Brief Summary

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Incontinence-associated dermatitis (IAD) is an inflammation of the skin caused by prolonged direct contact of the skin with urine and/or stool. Elderly and care-dependent people are often affected by this type of inflammation. Gentle skin cleansing and the use of skin protection products are recommended. Available skin protection products can be categorized into film-forming or lipophilic skin protectants depending on the ingredients and overall composition. There is no evidence about the superiority of one product compared to another regarding skin protection. The overall aim of this study is to compare the effects of two skin protection products compared to an untreated control group. An exploratory trial in elderly nursing home residents and geriatric patients will be conducted.

Detailed Description

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Incontinence-associated dermatitis (IAD) is an inflammation of the skin caused by prolonged and direct contact of the skin with urine and/or stool. It may occur in all age groups but elderly and care-dependent incontinent people are often affected by this type of inflammation. Promotion of continence, use of absorbent products and structured skin care are recommended to prevent and/or treat IAD. Available skin protection products can be categorized into film-forming or lipophilic skin protectants depending on the ingredients and overall composition. Currently, there is no evidence about the superiority of one product compared to another regarding skin protection. The overall aim of this study is to compare the effects of two skin protection products compared to an untreated control group. An exploratory randomized controlled trial in incontinent elderly nursing home residents and geriatric patients will be conducted. In the two intervention groups, a film-forming or a lipophilic skin protection product will be applied in addition to standardized skin care regimens. Every other day, investigators will perform skin inspections, including instrumental skin measurements to quantify erythema for a total study period of n= 14 days. IAD- related pain and itch will be assessed. A total of n= 210 nursing home residents and geriatric patients in Berlin, Germany, aged over 65 years, who are affected by urinary and faecal incontinence without signs of severe IAD will be included.

Conditions

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Incontinence-associated Dermatitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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ESENTA™ Skin Barrier Spray

In the intervention group I, standardized mild skin cleansing regimen and daily topical application of a film-forming skin protectant at the exposed skin areas will be applied by nursing staff.

Group Type EXPERIMENTAL

ESENTA™ Skin Barrier Spray (ConvaTec, UK)

Intervention Type OTHER

The skin protectant will be applied on clean and dry skin exposed to urine and stool. After application, the solvent evaporates leaving a silicone film on the skin surface.

Hydrophobes Basisgel DAC

In the intervention group II, standardized mild skin cleansing regimen and daily topical application of a hydrophobic skin protectant at the exposed skin areas will be applied by nursing staff.

Group Type EXPERIMENTAL

Hydrophobes Basisgel DAC

Intervention Type OTHER

The skin protectant will be applied on clean and dry skin. It contains 95% paraffin oil and creates a hydrophobic layer on the skin surface.

Standard Care

In the control group, standardized mild skin cleansing regimen without application of an additional skin protectant will be conducted by nursing staff.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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ESENTA™ Skin Barrier Spray (ConvaTec, UK)

The skin protectant will be applied on clean and dry skin exposed to urine and stool. After application, the solvent evaporates leaving a silicone film on the skin surface.

Intervention Type OTHER

Hydrophobes Basisgel DAC

The skin protectant will be applied on clean and dry skin. It contains 95% paraffin oil and creates a hydrophobic layer on the skin surface.

Intervention Type OTHER

Other Intervention Names

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Film-forming skin protectant Hydrophobic skin protectant

Eligibility Criteria

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Inclusion Criteria

* Geriatric patients or residents being incontinent of urine and stool
* Expected minimum length of stay of 14 days at the care facility
* Intact skin with no clinical signs of IAD OR
* intact skin with early clinical signs of IAD (IAD category 1A)
* Written informed consent

Exclusion Criteria

* Residents/patients at the end of life
* Residents/Patients with IAD category 1B, 2A, 2B and/or signs of clinical infection in the IAD area
* Any skin condition or wounds (at investigational areas of the skin) requiring additional treatment (e. g. pressure ulcers, intertrigo, infection)
* Known hypersensitivity or allergy to silicones and/or topical leave-on products
* Topical treatments in the IAD area.
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Charite University, Berlin, Germany

OTHER

Sponsor Role lead

Responsible Party

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Prof. Dr. Jan Kottner

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jan Kottner, Prof.

Role: PRINCIPAL_INVESTIGATOR

Charite University, Berlin, Germany

Locations

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Charité Universitätsmedizin Berlin

Berlin, , Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Jan Kottner, Prof.

Role: CONTACT

0049 30 450 529411

Monira El Genedy-Kalyoncu, MSc

Role: CONTACT

0049 30 450 529434

Facility Contacts

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Jan Kottner, PD Dr.

Role: primary

0049 30 450 529411

Monira El Genedy-Kalyoncu, MSc

Role: backup

0049 30 450 529434

References

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El Genedy-Kalyoncu M, Fastner A, Volzer B, Raeder K, Neumann K, Lahmann NA, Kottner J. Comparison of two skin protection regimes for the Prevention of Incontinence-associated Dermatitis in geriatric care (PID): a study protocol for an exploratory randomised controlled pragmatic trial. BMJ Open. 2022 Sep 29;12(9):e065909. doi: 10.1136/bmjopen-2022-065909.

Reference Type DERIVED
PMID: 36175092 (View on PubMed)

Other Identifiers

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01KG2020

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

PID

Identifier Type: -

Identifier Source: org_study_id

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