The Effects of High-intensity and Moderate-intensity Exercise on Polycystic Ovary Syndrome
NCT ID: NCT05394935
Last Updated: 2025-02-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
34 participants
INTERVENTIONAL
2020-01-01
2024-05-25
Brief Summary
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All participants will undergo a blood test. The investigators will then assess the participants cardiovascular fitness by means of a maximal exercise test and measure body composition through height, weight, and hip-to-waist ratio.
Participants will undergo an MRI, where the investigators will assess the participants brain structure and how the brain responds to a number of tests. The investigators will also conduct some tests that will assess the participants cognition, such as IQ, memory etc.
The investigators will measure the blood vessels leading to the brain and the blood flow through them to measure how much blood the brain receives when rested, using ultrasound.
The investigators will use a number of tests to look at brain function, measure the responses to these tests, and compare them between the normal, healthy women and those with PCOS. This will show if women with PCOS have a similar brain function when rested and when their brains are tested to those without the condition.
The investigators will use exercise as an intervention, where the aim will be to investigate whether women with PCOS respond similarly to those without the condition to both high-intensity and moderate-intensity exercise. The tests of brain function will be repeated following the exercise, and see if both normal, healthy women and those with PCOS have a similar response to the brain function tests.
All tests and measures will be compared between the PCOS group, and the healthy control group to establish any potential differences or similarities as a result of the condition.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
SINGLE
Study Groups
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Polycystic Ovary Syndrome
Women with PCOS
High-Intensity Exercise
Acute, low-volume HIIT 12x (1min:1min) Working intensity: \>85% heart rate reserve Resting intensity: Active rest
Moderate-Intensity Exercise
Continuous, MISS 50mins Working intensity: 50-60% heart rate reserve
Controls
Healthy, age and BMI matched controls
High-Intensity Exercise
Acute, low-volume HIIT 12x (1min:1min) Working intensity: \>85% heart rate reserve Resting intensity: Active rest
Moderate-Intensity Exercise
Continuous, MISS 50mins Working intensity: 50-60% heart rate reserve
Interventions
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High-Intensity Exercise
Acute, low-volume HIIT 12x (1min:1min) Working intensity: \>85% heart rate reserve Resting intensity: Active rest
Moderate-Intensity Exercise
Continuous, MISS 50mins Working intensity: 50-60% heart rate reserve
Eligibility Criteria
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Inclusion Criteria
* Inactive (less than 40 mins of structured exercise per week).
Exclusion Criteria
* Congenital adrenal hyperplasia, Cushing's syndrome, thyroid disease, hyperprolactinaemia and androgen secreting tumours.
* Known history of cardiovascular disease.
* Contraindications to MRI (fitted with ferromagnetic devices).
16 Years
50 Years
FEMALE
Yes
Sponsors
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Cardiff University
OTHER
Cardiff Metropolitan University
OTHER
Responsible Party
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Locations
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Cardiff Metropolitan University
Cardiff, , United Kingdom
Countries
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Other Identifiers
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STA-1653
Identifier Type: -
Identifier Source: org_study_id
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