14 Weeks Exercise Training on Lean Women With and Without PCOS

NCT ID: NCT02429128

Last Updated: 2016-08-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

22 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-07-31

Study Completion Date

2016-07-31

Brief Summary

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The aim of this project is to investigate the pathophysiology of PCOS in regards to the metabolic profile including defects in insulin sensitivity in skeletal muscle and adipose tissue, and to investigate the effects of exercise training on these parameters.

Detailed Description

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Conditions

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Polycystic Ovary Syndrome (PCOS)

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Lean PCOS training

14 weeks exercise training

Group Type ACTIVE_COMPARATOR

14 weeks exercise training

Intervention Type OTHER

Lean healthy controls

14 weeks exercise training

Group Type OTHER

14 weeks exercise training

Intervention Type OTHER

Interventions

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14 weeks exercise training

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Hyperandrogenism and/or hyperandrogenemia
* Regular menstruation
* Age: 20-40
* Inactive or low physical activity level
* Low to moderate fitness status


* Normal levels of plasma androgens
* Polycystic ovary and/or menstrual dysfunction
* Age: 20-40
* Inactive or low physical activity level
* Low to moderate fitness status

Exclusion Criteria

* Pregnancy or breast feeding
* Smoking
* Use of birth control pills 3 mo before enrolment
Minimum Eligible Age

20 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Copenhagen

OTHER

Sponsor Role lead

Responsible Party

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Solvejg Hansen

Cand Scient Human Physiology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Bente Kiens, Professor

Role: STUDY_DIRECTOR

NEXS, KU

Locations

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August Krogh Building

Copenhagen, Østerbro, Denmark

Site Status

Countries

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Denmark

References

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Hansen SL, Svendsen PF, Jeppesen JF, Hoeg LD, Andersen NR, Kristensen JM, Nilas L, Lundsgaard AM, Wojtaszewski JFP, Madsbad S, Kiens B. Molecular Mechanisms in Skeletal Muscle Underlying Insulin Resistance in Women Who Are Lean With Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2019 May 1;104(5):1841-1854. doi: 10.1210/jc.2018-01771.

Reference Type DERIVED
PMID: 30544235 (View on PubMed)

Other Identifiers

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Lean PCOS & Training

Identifier Type: -

Identifier Source: org_study_id

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