Intravoxel Incoherent Motion (IVIM) Magnetic Resonance Imaging in Multiple Sclerosis

NCT ID: NCT05391906

Last Updated: 2025-03-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-01-30

Study Completion Date

2026-12-30

Brief Summary

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Intravoxel incoherent motion (IVIM) is technique based on diffusion-weighted imaging (DWI). In this study, the investigators evaluate the use of IVIM in patients with Multiple Sclerosis.

Detailed Description

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Intravoxel incoherent motion (IVIM) is technique based on diffusion-weighted imaging (DWI), it is achieved through an MRI acquisition with multiple small b value to extract perfusion data. It has been shown to be a promising technique in evaluation of many brain conditions. This study seeks to assess intravoxel incoherent motion (IVIM) parameters in characterizing plaques and specific tissues in multiple sclerosis.

Conditions

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Multiple Sclerosis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Intravoxel Incoherent Motion(IVIM) MRI

Intravoxel incoherent motion (IVIM) is based on diffusion-weighted imaging (DWI)

Group Type EXPERIMENTAL

Diffusion-weighted magnetic resonance imaging

Intervention Type OTHER

Diffusion-weighted magnetic resonance imaging

Interventions

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Diffusion-weighted magnetic resonance imaging

Diffusion-weighted magnetic resonance imaging

Intervention Type OTHER

Other Intervention Names

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Diffusion-weighted magnetic resonance imaging uses the diffusion of water molecules to generate contrast in MR images.

Eligibility Criteria

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Inclusion Criteria

1. Patients who are 18 years or older.
2. Relapsing-remitting MS diagnosed as per Macdonald criteria

Exclusion Criteria

1. Contraindication to MRI. For example, metal implantation in the body, claustrophobia and pregnancy.
2. Patients who are unable to tolerate the scans without moving the head as a result of symptoms such as tremor, spasticity, involuntary movements and spasms, cognitive impairment, coughing, and shortness of breath.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Chinese University of Hong Kong

OTHER

Sponsor Role lead

Responsible Party

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Professor Tiffany So

Clinical Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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CUHK

Hong Kong, , Hong Kong

Site Status

Countries

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Hong Kong

Other Identifiers

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TiffanySo

Identifier Type: -

Identifier Source: org_study_id

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