Optimal Low B-value in Intravoxel Incoherent Motion Diffusion-weighted MR Imaging of the Brain

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-11-30

Study Completion Date

2014-12-31

Brief Summary

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Our research aims to reveal whether the low b-values distribution and the number of NEX for each b value will influence the accuracy of pseudodiffusion parameter derived from IVIM in brain.

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Detailed Description

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As an improved MRI technique, diffusion-weighted imaging (DWI) is considered the most sensitive for early pathological changes. Perfusion measurement has been shown to improve sensitivity and predictive value for tumor grading and prognosis, also as a predicator of recovery with reperfusion in patients of acute ischemic stroke.Our research aims to reveal whether the low b-values distribution and the number of NEX for each b value will influence the accuracy of pseudodiffusion parameter derived from IVIM in brain.

Conditions

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Healthy Volunteers

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Group 1

Low b=(0,50,150,200)，NEX=(1,3,2,2)

different low b-values distribution

Intervention Type OTHER

Group 2

Low b=(0,30,50,100,200)，NEX=(1,3,3,2,2)

different low b-values distribution

Intervention Type OTHER

Group 3

Low b=(0,30,60,90,120,150,180,200)，NEX=(1,3,3,3,2,2,2,2)

different low b-values distribution

Intervention Type OTHER

Group 4

Low b=(0,30,60,90,120,150,180,200)，NEX=(1,1,1,1,1,1,1,1)

No interventions assigned to this group

Group 5

Low b=(0,20,40,60,80,100,120,140,160,180,200)NEX=(1,3,3,3,3,2,2

different low b-values distribution

Intervention Type OTHER

Interventions

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different low b-values distribution

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* no hypertension or cerebral vascular diseases,
* no systemic metabolic disease;
* no infection or fever;
* no use of corticosteroid drugs;
* no MRI contraindication.

Minimum Eligible Age

25 Years

Maximum Eligible Age

35 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes