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Magnetic Resonance Imaging (MRI) Sequences Optimization in Healthy Subjects

NCT ID: NCT02900339

Last Updated: 2022-12-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

628 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-04-18

Study Completion Date

2021-10-12

Brief Summary

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Magnetic resonance imaging (MRI) is a noninvasive and non-ionizing (no use of X-rays) imaging modality. Today it is considered an anatomical and functional exploration reference technique. Since its inception around 1985, this technology is constantly evolving.

Many advances in MRI require constant adaptations of radiological practices. The morphological image is now associated with functional and parametric information (infusion, diffusion spectroscopy, etc ...). In parallel, work combining acquisition and post-processing of data also open new applications (tractography, functional MRI, etc ....). Thus, more and more procedures are necessary to "integrate" these techniques for the diagnosis and adapt to new demands of clinicians.

The type of sequence and its associated parameters allow to directly influence the contrast of images, to characterize tissue compared to another and, ultimately, to highlight morphological or functional abnormality. Image quality can be optimized on each MRI, depending on the time available for the acquisition on the one hand, and on the desired resolution and contrast, on the other hand. For each sequence, it is therefore necessary to find a compromise that will optimize the diagnostic quality of the examination.

This optimization requires a phase focusing on healthy volunteers. It is therefore important that researchers and physicists could design on healthy volunteers, the best settings of all parameters for an image or spectrum. Indeed, it is always necessary to properly optimize every parameter choices before beginning a study of a cohort of patients.

In this context, the main objective of this study is to optimize sequences and imaging protocols to evaluate and validate the choice of parameters in healthy volunteers.

Detailed Description

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Conditions

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Healthy Volunteers

Keywords

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MRI Sequence optimization Healthy volunteers

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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MR parameters optimization

The study will be conducted on the MRI of the Neurinfo platform, in the radiology department of the University Hospital of Rennes.

Group Type EXPERIMENTAL

Magnetic Resonance Imaging

Intervention Type DEVICE

MRI of the Neurinfo platform is an MRI 3 Tesla Magnetom Verio model, Siemens (Siemens Healthcare, Erlangen, Germany). This imager is marked for European Conformity (CE), ensuring compliance with European Union safety standards.

Interventions

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Magnetic Resonance Imaging

MRI of the Neurinfo platform is an MRI 3 Tesla Magnetom Verio model, Siemens (Siemens Healthcare, Erlangen, Germany). This imager is marked for European Conformity (CE), ensuring compliance with European Union safety standards.

Intervention Type DEVICE

Other Intervention Names

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Magnetom

Eligibility Criteria

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Inclusion Criteria

* Men or women aged over 18 years
* Written informed consent given

Exclusion Criteria

* contraindication to MRI :

* Claustrophobia
* morphotype not allowing access to MRI
* Wear a metallic implant, such as:
* Pacemaker (pacemaker)
* Ferromagnetic surgical clips
* Intra orbital metallic foreign bodies or encephalic
* Pregnancy
* Breastfeeding
* Adults under guardianship, trusteeship or safeguard justice
* No social Insurance
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Rennes University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jean-Christophe FERRE, MD, PhD

Role: STUDY_DIRECTOR

CHU Rennes

Locations

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Radiology Department CHU de Rennes

Rennes, , France

Site Status

Countries

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France

Other Identifiers

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2011-A01531-40

Identifier Type: OTHER

Identifier Source: secondary_id

35RC11_8965

Identifier Type: -

Identifier Source: org_study_id