Impact of Partial Capsule Decortication on Device-related Infection in Patients Receiving Cardiac Implantable Electronic Device Replacement

NCT ID: NCT05390216

Last Updated: 2024-06-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

1016 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-06-05

Study Completion Date

2030-05-31

Brief Summary

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Increasing number of cardiac implantable electronic devices (CIEDs) have been implanted in the worldwide every year, which is accompanied by the growing number of CIED-related infection, especially in patients with CIED replacement. This multicenter, prospective, single-blinded, randomized controlled trial is to confirm the impact of partial capsule decortication on device-related infection in patients receiving CIED replacement.

Detailed Description

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Conditions

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Pacemaker Complication Infections

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Partial capsule decortication

Group Type EXPERIMENTAL

Partial capsule decortication

Intervention Type PROCEDURE

The anterior wall of the capsule was removed during the operation.

Without partial capsule decortication

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Partial capsule decortication

The anterior wall of the capsule was removed during the operation.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patient is at least 18 years of age
* Patient is planned to undergo at least one of the following procedures:

a) Patient has existing CIED (pacemaker, or CRT-P, or ICD, or CRT-D) and is undergoing pulse generator replacement or upgrade with a new generator. b) Patients planned to have leads added, or extracted and added for upgrades.
* Patient is willing to sign and date informed consent

Exclusion Criteria

* History of CIED-related infection
* Open the pocket for any reason within the last one year
* Any evidence indicating active infection
* Requirement of long term vascular access for any reason
* Expected survival time is less than one year
* Patients who were pregnant or breastfeeding
* Participation in another study that may confound the results of this study
* Patient is unable to comply with scheduled follow up
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Shanghai Zhongshan Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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180 Fenglin Road

Shanghai, Shanghai Municipality, China

Site Status

Countries

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China

Other Identifiers

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12901

Identifier Type: -

Identifier Source: org_study_id

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