miRNA in Patients With Thoracic, Abdominal and Intracranial Aneurysms

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

35 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-05-19

Study Completion Date

2021-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

To assess the expression of miRNA in patients with TAA, AAA in aneurysmatic tissue and to compare this expression with the healthy tissue in the same patient.

In the same cohort, to asses the presence of miRNA in plasma and to compare with the control group.

Over the period of three years,to follow subjects in order to assess if the presence of certain miRNAs speeds up or slows down the progression of disease.

In patients with intracranial aneurysms to detect miRNA in plasma especially in patients with familial occurrence.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Role of Circulating MicroRNAs in Pathogenesis of Aneurysms of the Abdominal and Thoracic Aorta - Study "Micro AAA"

NCT03090763

Aortic Aneurysm

UNKNOWN

Circulating microRNAs and Degenerative Abdominal Aorta Aneurysm

NCT03974958

Abdominal Aorta Aneurysm

COMPLETED NA

Occurrence of Abdominal Aortic Aneurysms in Patients With Aneurysmal Subarachnoid Hemorrhage

NCT07312565

Aneurysm Abdominal Cerebral Aneurysm Ruptured

NOT_YET_RECRUITING

Comparison of a Full Automatic Software With Standard Methods of Vessels Analysis

NCT05920317

Abdominal Aortic Aneurysm

UNKNOWN

Screening for Thoracic Aortic Aneurysm Among a Cohort of Patients With a Degenerative Abdominal Aortic Aneurysm

NCT01599533

Abdominal Aortic Aneurysms

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

MicroRNAs constitute a recently discovered class of non-coding RNAs that play key roles in the regulation of gene expression. Acting at the post-transcriptional level, MicroRNAs have been shown to be involved in a wide range of biological processes such as cell cycle control, apoptosis and several developmental and physiological processes including stem cell differentiation, hematopoiesis, hypoxia, cardiac and skeletal muscle development. In addition to their important roles in healthy individuals, microRNAs have also been implicated in a number of diseases including a broad range of cancers, cardiovascular and heart disease. Their different expression in aortic tissue in patients with aortic abdominal aneurysm and their association with the progression of the disease were confirmed. They represent the potential target for the treatment of the disease. MiRNA act as biomarkers showing the potential risk of the presence of TAA, AAA and intracranial aneurysm, for the prediction of TAA and AAA progression and for the discovery of new treatment possibilities.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Vascular Aneurysm

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Patients Controls

Control group

ngs next generation sequencing

Intervention Type DIAGNOSTIC_TEST

the samples from aneurysmatic tissue and healthy aortic tissue will be investigated using NGS

Patients with aneurysma

ngs next generation sequencing

Intervention Type DIAGNOSTIC_TEST

the samples from aneurysmatic tissue and healthy aortic tissue will be investigated using NGS

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

ngs next generation sequencing

the samples from aneurysmatic tissue and healthy aortic tissue will be investigated using NGS

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. 18 years of age or older
2. Patient willing and able to sign clinical trial Informed Consent
3. Patient with AAA or TAA who require an open surgical procedure, or patient with intracranial aneurysm indicated for radiological intervention