A Clinical Comparison of the Effectiveness of Two Moisture Insensitive Primers on Orthodontic Attachment Bond

NCT ID: NCT05345379

Last Updated: 2022-04-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

33 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-04-11

Study Completion Date

2022-12-31

Brief Summary

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A single-operator, randomized controlled trial (RCT) will be conducted to evaluate the clinical effectiveness of moisture insensitive primers (MIPs) in bonding molar tubes under moisture contaminated conditions by comparing the clinical bond failure and survival rate of molar tubes using two MIPs which are Transbond ™ MIP (3M Unitek Dental Products, Monrovia, CA, USA) and Assure® Plus-All Surface Light Cure Bonding Primer (Reliance, Itasca, IL, USA).

Detailed Description

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A single-operator, a multi-centre, a split-mouth, cross-quadrant RCT, with 1:1 allocation ratio will be conducted for patients seeking for orthodontic treatment with fixed orthodontic appliance. The study will be conducted at postgraduate Orthodontic Clinic/ College of Dentistry/University of Baghdad in addition to private dental clinics in Baghdad, Iraq. Patients seeking for orthodontic treatment and their treatment will be planned with metal fixed orthodontic appliance (0.22" for both arches) will be recruited for this trial. Patients who will met the eligible criteria will be randomly assigned to either group of primer type. A single operator to avoid inter-operator variation will bond all molar tubes. A standardized protocol of tooth preparation and molar tubes bonding will be adopted for all the patients. All teeth will be isolated and cleansed with a mixture of water and pumice using a rubber-polishing cup on a low speed hand piece. The teeth will be rinsed and dried with an oil-free air syringe, and will be etched with the conventional acid etching technique (37% orthophosphoric acid applied for 30sec). They will be subsequently rinsed thoroughly with water for 10sec to ensure total removal of etchant according to the manufacturer's instructions.

Without drying, one coat of the patient own non-stimulated saliva will be applied to the etched and wet surface using bond brush; the excess will be blotted with a moist cotton pellet maintaining the surface moist.

A liberal coat of the MIP will be applied to the etched area of the teeth destined for a specific primer (split-mouth) using a nylon bond brush. Air will be gently blown on each tooth for 2sec, aiming the air stream perpendicular to the enamel surface then light cured for 20sec. After etching and priming, molar tubes will be bonded to the teeth with a light-cured adhesive according to the manufacturer's instructions.

Initial wires will be fitted 10-15mins after bonding completion in the context of the straight wire technique.

All patients will receive the same instructions and will be seen at 3-4-week intervals. They will be, however, requested to inform the operator immediately and attend as soon as possible once a bond failure was apparent. the molar tubes bond survival will be followed up for 6 months. They will be instructed to brush with a manual toothbrush using a fluoride-containing toothpaste.

Conditions

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Dental Bonding

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

The primers will be randomly allocated using a split-mouth, cross-quadrant design. In each patient, two diagonal quadrants (i.e. upper right and lower left, or vice versa) will be randomly assigned to each primer group.
Primary Study Purpose

SCREENING

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors
This trial will be triple-blinded in which neither the participants nor the trial team will know which one of the primers a patient has received, as well as the outcome assessor will be blinded. This can be achieved by placing the two primers in two similar masked bottles and giving them numerical coding i.e. number one and number two coding for either type of primer.

Study Groups

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Transbond MIP

Transbond primer group will be randomly allocated using a split-mouth, cross-quadrant design and two diagonal quadrants (i.e. upper right and lower left, or vice versa) for each participant.

Group Type EXPERIMENTAL

Single intervention

Intervention Type OTHER

Single intervention at the day of fixed orthodontic appliance bonding

Assure plus

Assure Plus primer group will be randomly allocated using a split-mouth, cross-quadrant design and two diagonal quadrants (i.e. upper right and lower left, or vice versa) for each participant.

Group Type EXPERIMENTAL

Single intervention

Intervention Type OTHER

Single intervention at the day of fixed orthodontic appliance bonding

Interventions

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Single intervention

Single intervention at the day of fixed orthodontic appliance bonding

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients seeking for metal fixed orthodontic appliance with 0.22"\*0.28";
* Complete set of permanent dentition with fully erupted molar teeth on both arches;
* Intact 1st molars and mainly their buccal surfaces are free from caries, fillings, or gingival hyperplasia;

Exclusion Criteria

* Patients with systemic problem or genetic syndrome that affecting enamel surface like patients with generalized enamel hypoplasia.
* Patients exhibit parafunctional habits;
* Patients who their treatment plan need appliance that soldered on molar bands.
* No occlusal interferences that can affect the ideal position of molar tubes, especially in the lower arch.
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Baghdad

OTHER

Sponsor Role lead

Responsible Party

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Ahmed Abdulelah Abduljawad

orthodontics master student

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Harraa S Abdulameer, B.D.S, PhD

Role: STUDY_DIRECTOR

Baghdad college of dentistry, Department of orthodontics

Ahmed A Abduljawad, B.D.S

Role: PRINCIPAL_INVESTIGATOR

Baghdad college of dentistry, Department of orthodontics

Locations

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Baghdad college of dentistry

Baghdad, , Iraq

Site Status RECRUITING

Countries

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Iraq

Central Contacts

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Ahmed A Abduljawad, B.D.S

Role: CONTACT

+9647705429007 ext. +964

Harraa S Abdulameer, B.D.S, PhD

Role: CONTACT

+9647904546371 ext. +964

Facility Contacts

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Ahmed A Abduljawad, B.D.S

Role: primary

+9647705429007 ext. +964

Harra S Abdulameer, B.D.S, PhD

Role: backup

+9647904546371 ext. +964

References

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Zeppieri IL, Chung CH, Mante FK. Effect of saliva on shear bond strength of an orthodontic adhesive used with moisture-insensitive and self-etching primers. Am J Orthod Dentofacial Orthop. 2003 Oct;124(4):414-9. doi: 10.1016/s0889-5406(03)00405-0.

Reference Type BACKGROUND
PMID: 14560272 (View on PubMed)

Endo T, Ozoe R, Sanpei S, Shinkai K, Katoh Y, Shimooka S. Effects of moisture conditions of dental enamel surface on bond strength of brackets bonded with moisture-insensitive primer adhesive system. Odontology. 2008 Jul;96(1):50-4. doi: 10.1007/s10266-007-0083-7. Epub 2008 Jul 27.

Reference Type BACKGROUND
PMID: 18661205 (View on PubMed)

Goswami A, Mitali B, Roy B. Shear bond strength comparison of moisture-insensitive primer and self-etching primer. J Orthod Sci. 2014 Jul;3(3):89-93. doi: 10.4103/2278-0203.137695.

Reference Type BACKGROUND
PMID: 25143933 (View on PubMed)

Paschos E, Westphal JO, Ilie N, Huth KC, Hickel R, Rudzki-Janson I. Artificial saliva contamination effects on bond strength of self-etching primers. Angle Orthod. 2008 Jul;78(4):716-21. doi: 10.2319/0003-3219(2008)078[0716:ASCEOB]2.0.CO;2.

Reference Type BACKGROUND
PMID: 18302473 (View on PubMed)

Roelofs T, Merkens N, Roelofs J, Bronkhorst E, Breuning H. A retrospective survey of the causes of bracket- and tube-bonding failures. Angle Orthod. 2017 Jan;87(1):111-117. doi: 10.2319/021616-136.1. Epub 2016 Jun 15.

Reference Type BACKGROUND
PMID: 27304230 (View on PubMed)

Hadrous R, Bouserhal J, Osman E. Evaluation of shear bond strength of orthodontic molar tubes bonded using hydrophilic primers: An in vitro study. Int Orthod. 2019 Sep;17(3):461-468. doi: 10.1016/j.ortho.2019.06.006. Epub 2019 Jul 2.

Reference Type BACKGROUND
PMID: 31278045 (View on PubMed)

Gange P. The evolution of bonding in orthodontics. Am J Orthod Dentofacial Orthop. 2015 Apr;147(4 Suppl):S56-63. doi: 10.1016/j.ajodo.2015.01.011.

Reference Type BACKGROUND
PMID: 25836345 (View on PubMed)

Provided Documents

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Document Type: Study Protocol, Statistical Analysis Plan, and Informed Consent Form

View Document

Related Links

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Other Identifiers

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594422

Identifier Type: -

Identifier Source: org_study_id

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