A Bite Force Study Comparing Two New Test Adhesives With Currently Marketed Denture Adhesive

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-03-07

Study Completion Date

2017-04-05

Brief Summary

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The objective of this 4-treatment, 4-period, randomized, crossover, proof of principle bite force study will be to compare bite force measurements over a 12 hour period across two (test) cream denture adhesives, with a currently marketed cream denture adhesive (positive control), and a negative/no treatment control.

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Detailed Description

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This will be a 4-treatment, 4-period, randomized, crossover, proof of principle bite force study which will compare bite force measurements over a 12 hour period across two cream denture adhesives with a currently marketed cream denture adhesive (positive control), and a negative/no treatment control. A short questionnaire regarding the flavor and texture characteristics of each denture adhesive after a single use will also be administered to give an indication of participant satisfaction of these attributes.

Conditions

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Denture Retention

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Test Product 1

Applied topically to upper denture, to clean dry denture fit surface in a pattern consistent with application instructions.

Group Type EXPERIMENTAL

Test Product 1

Intervention Type DEVICE

Test adhesive 1 with a thin nozzle

Test Product 2

Applied topically to upper denture, to clean dry denture fit surface in a pattern consistent with application instructions.

Group Type EXPERIMENTAL

Test Product 2

Intervention Type DEVICE

Test adhesive 2 with a thin nozzle

Reference Product

Applied topically to upper denture, to clean dry denture fit surface in a pattern consistent with application instructions.

Group Type ACTIVE_COMPARATOR

Reference Product

Intervention Type DEVICE

Adhesive Cream

Negative Control

Group Type OTHER

Negative Control

Intervention Type OTHER

No adhesive

Interventions

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Test Product 1

Test adhesive 1 with a thin nozzle

Intervention Type DEVICE

Test Product 2

Test adhesive 2 with a thin nozzle

Intervention Type DEVICE

Reference Product

Adhesive Cream

Intervention Type DEVICE

Negative Control

No adhesive

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Demonstrates understanding of the study procedures, restrictions and willingness to participate as evidenced by voluntary written informed consent and has received a signed and dated copy of the informed consent form.
* Aged between 18 to 85 years.
* Good general and mental health with, in the opinion of the investigator or medically qualified designee: No clinically significant and relevant abnormalities in medical history or upon oral examination and absence of any condition that could affect the participant's safety or wellbeing or their ability to understand and follow study procedures and requirements.
* Completely edentulous maxillary arch restored with a conventional full acrylic based upper complete denture. Dentate, partial or full edentulous mandibular arch. Partial or full edentulous arch may be restored with a stable complete, partial or implant supported denture. Maxillary dentures must be considered to be moderately well-fitting at the screening visit (Kapur Index, Olshan Modification: retention score \>=2, stability score \>=2). Maxillary dentures and mandibular dentures, if present, must be considered to be well-made based on design and construction criteria specified in the protocol. The qualifying maxillary incisal bite force readings (without adhesive) must be less than or equal to 9 pounds (lb) at the Screening Visit and subsequent visit pre-treatment baseline bites. At least 2 of the 4 qualifying bite readings at the Screening Visit must be reproducible (+/- 2lb). At subsequent visits the bite force readings must be within +/-2lb for 1 of the 3 practice bites and the pre-treatment baseline bite.
* Understands and is willing, able and likely to comply with all study procedures and restrictions.

Exclusion Criteria

* A woman who is known to be pregnant or who is intending to become pregnant (self reported) over the duration of the study.
* A woman who is breast-feeding.
* Implanted with a cardiac pacemaker.
* Daily doses of medication that might interfere with the ability to perform the study according to protocol (as determined by the Investigator).
* Taking or have taken a bisphosphonate drug for treatment of osteoporosis.
* A serious chronic disease requiring hospitalization.
* Any condition not previously mentioned that in the Investigator's opinion may impair the study evaluation.
* Known or suspected intolerance or hypersensitivity to the study materials (or closely related compounds) or any of their stated ingredients.
* Any clinically significant or relevant oral abnormality (e.g. temporomandibular joint \[TMJ\] problems) that, in the opinion of the investigator, could affect the participant's participation in the study.
* Any participant clinically identified as having an incisal bite relation which could affect the bite force measurements.
* Severe dry mouth that may affect denture retention in the opinion of the Investigator.
* OST examination findings such as stomatitis, open sores, lesions, redness or swelling that, in the opinion of the investigator, could affect the participant's participation in the study.
* Participation in another clinical study (including cosmetic studies) or receipt of an investigational drug within 30 days of the screening visit.
* Previous participation in this study.
* Recent history (within the last year) of alcohol or other substance abuse.
* A participant who is unwilling to refrain from smoking, including e-cigarettes and the use of chewing tobacco or other tobacco products for the duration of screening and each treatment day (12-14 hours).
* An employee of the sponsor or the study site or members of their immediate family.

Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes