Role OF Geometric Mean in Estimation OF Differential Renal Function in DMSA Scintigraphy
NCT ID: NCT05344807
Last Updated: 2022-04-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
100 participants
OBSERVATIONAL
2022-05-31
2022-11-30
Brief Summary
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The relative renal function (RRF), expressed as a percent of total renal function, is important in the initial assessment and treatment of patients having renal diseases. RRF has traditionally been measured by radionuclide renal scintigraphies using different tracers for a long time . Different radiopharmaceuticals such as technetium-99m-diethylenetriaminepentaacetic acid (99mTc-DTPA), technetium-99m-dimercaptosuccinic acid (99mTc-DMSA), technetium-99m-mercaptoacetyltriglycine (99mTc-MAG3).
99mTc-DMSA is a static agent that is actively taken up by the proximal and distal renal tubular cells, directly from the peritubular vessels and accumulates in the renal cortex. Its binding level to protein in mammals is 90% which prevents significant glomerular filtration. DMSA renal scan images provide a good definition of the cortical outline, as well as they show the relative distribution of functional tissue.
Determination of the left to right dimercaptosuccinic acid (DMSA) uptake ratio is theoretically one of the easiest quantitative procedures in nuclear medicine. The quantification can be performed on the posterior view, with or without the lateral view for correction of kidney depth. The geometric mean can also be determined using both the anterior and the posterior views.
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Detailed Description
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Conditions
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Study Design
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CASE_ONLY
CROSS_SECTIONAL
Interventions
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Renal DMSA Scintigraphy
patient injected with Tc99mDMSA then imaged after 2-4 hours by gamma camera
Eligibility Criteria
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Inclusion Criteria
* Patients aging 2 to 70 years
Exclusion Criteria
* Patients with a major uncontrollable medical illness.
2 Years
70 Years
ALL
No
Sponsors
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Sohag University
OTHER
Responsible Party
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Shrouk Atef Abdelsalam
resident doctor at Nuclear medicine, Oncology department Sohag university hospital
Locations
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Sohag University Hospital
Sohag, , Egypt
Countries
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Central Contacts
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Mohamed s gaber, professor
Role: CONTACT
Facility Contacts
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Osama R ElSherif, professor
Role: primary
References
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Arteaga MV, Caballero VM, Rengifo KM. Dosimetry of 99mTc (DTPA, DMSA and MAG3) used in renal function studies of newborns and children. Appl Radiat Isot. 2018 Aug;138:25-28. doi: 10.1016/j.apradiso.2017.07.054. Epub 2017 Jul 28.
Hervas I, Marti JF, Gonzalez A, Ruiz JC, Alonso J, Bello P, Manzano F, Torres I, Mateo A. Is the depth correction using the geometric mean really necessary in a 99Tcm-DMSA scan in the paediatric population? Nucl Med Commun. 2001 May;22(5):547-52. doi: 10.1097/00006231-200105000-00013.
Miyazaki C, Harada H, Shuke N, Okizaki A, Miura M, Hirano T. (99m)Tc-DTPA dynamic SPECT and CT volumetry for measuring split renal function in live kidney donors. Ann Nucl Med. 2010 Apr;24(3):189-95. doi: 10.1007/s12149-010-0349-y. Epub 2010 Mar 9.
Other Identifiers
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Soh-Med-22-04-06
Identifier Type: -
Identifier Source: org_study_id
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