Estimation of Glomerular Filtration Rate (GFR) in Patients With Type 2 Diabetes Mellitus.

NCT ID: NCT01215994

Last Updated: 2015-04-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

600 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-03-31

Study Completion Date

2016-03-31

Brief Summary

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The purpose of the present study is to evaluate bias, precision and accuracy of new cystatin C and creatinine based equations for GFR estimation compared with 51Cr-EDTA (chromium-51 labeled ethylenediamine tetraacetic acid) measured GFR in patients with diabetes.

Detailed Description

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The purpose of the present study is to evaluate bias, precision and accuracy of new cystatin C and creatinine based equations for GFR estimation compared with 51Cr-EDTA measured GFR in patients with diabetes.

Additional, we will check which equation detects better the reduction of renal function over the time, in patients with diabetes.

Finally, we will investigate if cystatin C levels can be influenced by factors other than GFR

Conditions

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Diabetes Mellitus Diabetic Nephropathy

Study Design

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Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* Type 2 and type 1 diabetes mellitus

Exclusion Criteria

* Patients with other type diabetes: gestational, exocrine pancreatic defects, endocrinopathies, drugs
* Patients with end-stage renal disease, cardiac failure, hepatic failure, malignancies, immunosuppression, pregnant, diabetic ketoacidosis
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AHEPA University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Fotios Iliadis

MD, ASSISTANT PROFESSOR

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Dimitrios Grekas, PhD, MD

Role: STUDY_CHAIR

Aristotle University of Thessaloniki, Greece

Locations

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AHEPA University Hospital of Thessaloniki

Thessaloniki, , Greece

Site Status RECRUITING

Countries

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Greece

Central Contacts

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Fotios Iliadis, MD, PhD

Role: CONTACT

2310993472 ext. 0030

References

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Iliadis F, Didangelos T, Ntemka A, Makedou A, Moralidis E, Gotzamani-Psarakou A, Kouloukourgiotou T, Grekas D. Glomerular filtration rate estimation in patients with type 2 diabetes: creatinine- or cystatin C-based equations? Diabetologia. 2011 Dec;54(12):2987-94. doi: 10.1007/s00125-011-2307-1. Epub 2011 Sep 23.

Reference Type DERIVED
PMID: 21947381 (View on PubMed)

Other Identifiers

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AHEPA

Identifier Type: -

Identifier Source: org_study_id

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