Impact of a Family History of Hypertension and Physical Activity on Left Ventricular Mass

Study Results

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

74 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-04-19

Study Completion Date

2020-02-27

Brief Summary

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This is a retrospective analysis of data collected within two previous studies. The data has been combined and used to investigate the impact of having a family history of hypertension on left ventricular muscle mass with and without controlling for moderate and vigorous intensity physical activity frequency per week. The hypothesis was that in a sample of mostly active participants, no differences in left ventricular mass between family history of hypertension groups would be observed, but the positive family history of hypertension group would have elevated left ventricular mass compared to the negative family history of hypertension group following statistical control of activity frequency.

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Detailed Description

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A positive family history of hypertension (FHH) (+FHH) is associated with elevated left ventricular mass (LVM). Regular physical activity (PA) may eliminate differences in LVM between +FHH and negative family history of hypertension (-FHH) adults. PURPOSE: To determine if a +FHH is associated with a greater LVM compared to a -FHH group within a sample of young, mostly active healthy adults with and without statistically controlling for PA. METHODS: Healthy young (18-32yrs) participants self-reported FHH status and habitual moderate and vigorous PA frequency. Participants then underwent an echocardiogram.

Conditions

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Genetic Predisposition Genetic Hypertension

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Positive Family History of Hypertension

Young normotensive generally healthy adult with one or more biological parents with diagnosed hypertension.

Family history of hypertension

Intervention Type OTHER

Presence or absence of a family history of hypertension in a cross sectional study design.

Negative Family History of Hypertension

Young normotensive generally healthy adult with no biological parent with diagnosed hypertension.

No interventions assigned to this group

Interventions

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Family history of hypertension

Presence or absence of a family history of hypertension in a cross sectional study design.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Generally healthy

Exclusion Criteria

* Known hypertension, cardiovascular disease, current pregnancy, current infectious disease, diabetes mellitus, kidney disease, a history of cancer, pulmonary disease, history of a stroke, obesity (for most people this means a body mass index greater than 30), or any life threatening chronic conditions

Minimum Eligible Age

18 Years

Maximum Eligible Age

32 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes