The Genetics of Dilated Cardiomyopathy: A Quebec-Based Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-01-31

Study Completion Date

2008-12-31

Brief Summary

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Dilated cardiomyopathy (DCM) affects about 200,000 Canadians. Eighty percent of these cases are of unclear cause, often occuring in families. We believe that mutations in specific already-identified genes contribute to DCM in Quebec and that certain mutations may account for a significant proportion of cases due to the well-documented "founder effect". Two hundred patients with DCM followed in our Heart Function Clinic will be approached for one blood sample at their routine clinic visit to test this hypothesis. The samples will be tested in the Laboratory of Cardiovascular Genetics at the Royal Victoria Hospital.

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Detailed Description

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Conditions

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Dilated Cardiomyopathy (DCM)

Study Design

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Observational Model Type

FAMILY_BASED

Study Time Perspective

PROSPECTIVE

Interventions

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blood test

looking at DNA

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Followed at MUHC Heart Function Centre
* Documented EF of less than or equal to 35% and an enlarged heart with a left ventricular end-diastolic size of greater than 6 cm.
* Patient's written consent

Exclusion Criteria

* Patients with a known underlying condition that results in a weakened and enlarged heart
* Patients unable to read and understand the consent form
* Patients who do not wish to participate

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No