HIF-1 Alpha, VEGF and MMP-8 Levels in PICF of Smokers Versus Non Smokers

NCT ID: NCT05325918

Last Updated: 2022-04-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

14 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-08-29

Study Completion Date

2022-01-30

Brief Summary

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Smoking is a major risk factor for developing peri-implantitis so the current study is comparing inflammatory markers in smokers versus non smokers to know if they have a potential role in pathogenesis of peri-implantitis

Detailed Description

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Peri -implant crevicular fluid was obtained from seven smoker patients and then compared to peri-implant crevicular fluid from seven non smoker individuals.

The peri-implant crevicular fluid was obtained using periopaper strips then analyzed using ELISA kits of these markers; HIF-1 Alpha, VEGF and MMP-8

Conditions

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Peri-Implantitis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* Medically free patients
* Individuals with restored implants placed one year or more before study enrollment
* Both genders
* Age range 20-50 years old

Exclusion Criteria

* Pregnant Females
* Lactating females
Minimum Eligible Age

20 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Future University in Egypt

OTHER

Sponsor Role lead

Responsible Party

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Sarah Elkot

Lecturer of Oral Medicine, Periodontology and Diagnosis, Faculty of Oral and Dental Medicine, Future University in Egypt, Cairo, Egypt.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sarah M Elkot, Lecturer

Role: PRINCIPAL_INVESTIGATOR

Lecturer of Oral Medicine and Periodontology

Locations

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Faculty of oral and dental medicine,FUE, Cairo,Egypt

Cairo, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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FUE13

Identifier Type: -

Identifier Source: org_study_id

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