Resistance Exercise, Metabolism and Time of Day

NCT ID: NCT05321914

Last Updated: 2025-03-30

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 36 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-05-01
• Study Completion Date: 2024-02-01

Brief Summary

The aim of the current study is to determine the effect of time of day on the muscle and metabolic responses to resistance exercises in obese or overweight adults. To achieve this aim we have the following objectives:

1. Compare the effects of resistance exercise training performed in the morning vs the evening on insulin sensitivity

2. Compare the effects of resistance exercise training performed in the morning vs the evening on gains in muscle mass and strength

3. Compare the acute glucose responses to resistance exercise performed in the morning vs the evening

Conditions

Metabolic Disease

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Control

Habitual physical activity

Group Type: NO_INTERVENTION

No interventions assigned to this group

Morning exercise

Exercise training in the morning (6:00-10:00am)

Group Type: EXPERIMENTAL

Exercise training

Intervention Type: BEHAVIORAL

Exercise will consist of 1 set x 9 exercises x 3 sessions per week x 6 weeks. The load to be used during training will be calculated as 80% of one-repetition maximum (1RM) with each set performed to failure. 1RM will be re-tested on week 3, and the load adjusted accordingly, and upon completion of the study. During the training period, all sessions of training will be supervised by the researcher. The following exercises will be performed: Bench press, biceps curl, lat pull down, overhead press, lateral raise, leg extension, leg curl and calf raise.

Evening exercise

Exercise training in the evening (4:00-8:00pm)

Group Type: EXPERIMENTAL

Exercise training

Intervention Type: BEHAVIORAL

Exercise will consist of 1 set x 9 exercises x 3 sessions per week x 6 weeks. The load to be used during training will be calculated as 80% of one-repetition maximum (1RM) with each set performed to failure. 1RM will be re-tested on week 3, and the load adjusted accordingly, and upon completion of the study. During the training period, all sessions of training will be supervised by the researcher. The following exercises will be performed: Bench press, biceps curl, lat pull down, overhead press, lateral raise, leg extension, leg curl and calf raise.

Interventions

Exercise training

Exercise will consist of 1 set x 9 exercises x 3 sessions per week x 6 weeks. The load to be used during training will be calculated as 80% of one-repetition maximum (1RM) with each set performed to failure. 1RM will be re-tested on week 3, and the load adjusted accordingly, and upon completion of the study. During the training period, all sessions of training will be supervised by the researcher. The following exercises will be performed: Bench press, biceps curl, lat pull down, overhead press, lateral raise, leg extension, leg curl and calf raise.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• pass the physical activity readiness questionnaire
• body mass index (BMI) >27kg/m² and limited to 40 kg/m².

Exclusion Criteria

• Prior surgery for weight loss
• Prior history of heart, lung, cancer, endocrine or liver disease
• Participating in more than 1 hour structured exercise training per week

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Glasgow

OTHER

Sponsor Role: lead

Responsible Party

Stuart Gray

Senior Lecturer

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Stuart Robert Gray

Glasgow, , United Kingdom

Countries

United Kingdom

Other Identifiers

200210068

Identifier Type: -

Identifier Source: org_study_id