Evaluation of the Impact of SpO2 Averaging Time on Performance of an Automatic FiO2 Control System: a Randomized Study

NCT ID: NCT05274386

Last Updated: 2025-03-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-02-17

Study Completion Date

2022-12-30

Brief Summary

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The aim of the study is to determine the preferred oximeter averaging setting during automated control of FiO2 (A-FiO2) in infants receiving respiratory support and supplemental oxygen.

Detailed Description

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There are 7 different averaging time settings available with PRICO (Acutronic Medical Systems AG, Hirzel, Switzerland), but after over a year of experience there is no clear clinical impression of the best setting. Therefore, a small systematic study is needed to determine the optimal guidelines.

Conditions

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Neonatal Respiratory Distress Very Low Birth Weight Infant

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Subjects will be switched between 3 averaging times (4to6s-10s-16s) every 12 hours. The sequence will be assigned in random order. Each enrolled subject will continue in the study with regular changes in averaging time through the course of their need for A-FiO2.
Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Participants

Study Groups

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Averaging time 4to6 s

The SpO2 averaging time will be set to 4to6 s for the next 12 hours. All elements of care will be as routinely used, except the changing of the averaging time setting.

Group Type OTHER

Fabian ventilator with PRICO system (Acutronic Medical Systems AG, Hirzel, Switzerland); SpO2 averaging time set to 4to6 s

Intervention Type DEVICE

The SpO2 averaging time will be set to 4to6 s for the next 12 hours.

Averaging time 10 s

The SpO2 averaging time will be set to 10 s for the next 12 hours. All elements of care will be as routinely used, except the changing of the averaging time setting.

Group Type OTHER

Fabian ventilator with PRICO system (Acutronic Medical Systems AG, Hirzel, Switzerland); SpO2 averaging time set to 10 s

Intervention Type DEVICE

The SpO2 averaging time will be set to 10 s for the next 12 hours.

Averaging time 16 s

The SpO2 averaging time will be set to 16 s for the next 12 hours. All elements of care will be as routinely used, except the changing of the averaging time setting.

Group Type OTHER

Fabian ventilator with PRICO system (Acutronic Medical Systems AG, Hirzel, Switzerland); SpO2 averaging time set to 16 s

Intervention Type DEVICE

The SpO2 averaging time will be set to 16 s for the next 12 hours.

Interventions

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Fabian ventilator with PRICO system (Acutronic Medical Systems AG, Hirzel, Switzerland); SpO2 averaging time set to 4to6 s

The SpO2 averaging time will be set to 4to6 s for the next 12 hours.

Intervention Type DEVICE

Fabian ventilator with PRICO system (Acutronic Medical Systems AG, Hirzel, Switzerland); SpO2 averaging time set to 10 s

The SpO2 averaging time will be set to 10 s for the next 12 hours.

Intervention Type DEVICE

Fabian ventilator with PRICO system (Acutronic Medical Systems AG, Hirzel, Switzerland); SpO2 averaging time set to 16 s

The SpO2 averaging time will be set to 16 s for the next 12 hours.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* All VLBW on respiratory support and oxygen requirements after 2 weeks of age in the NICU are eligible after parental informed consent is obtained.

Exclusion Criteria

* Parental informed consent is not obtained
* Recording device for automated control of FiO2 is not available
Minimum Eligible Age

2 Weeks

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Motol University Hospital

OTHER

Sponsor Role collaborator

Czech Technical University in Prague

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jan Janota, PhD

Role: PRINCIPAL_INVESTIGATOR

Motol University Hospital

Thomas E Bachman, MSc

Role: PRINCIPAL_INVESTIGATOR

Czech Technical University in Prague

Veronika Rafl-Huttova, MSc

Role: PRINCIPAL_INVESTIGATOR

Czech Technical University in Prague

Jakub Rafl, PhD

Role: PRINCIPAL_INVESTIGATOR

Czech Technical University in Prague

Locations

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Motol University Hospital

Prague, , Czechia

Site Status

Countries

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Czechia

Other Identifiers

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PricoOptisatAvg

Identifier Type: -

Identifier Source: org_study_id

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