The Relationship Between Brain MRI Phenotypes, Genes and Cognitive Outcome in CHD Adults
NCT ID: NCT05258981
Last Updated: 2023-08-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
225 participants
INTERVENTIONAL
2022-07-01
2026-06-30
Brief Summary
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Detailed Description
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Aim 2 is designed to determine the relationship between structural connectivity using rich club (measured by MRI) and executive function in adults with d-TGA and if this relationship is modified by (a) presence of neuroresilience gene ApoE ε2 or ε4 alleles or (b) damaging variants in hypoxia response genes.
In Aim 3, the investigators will determine the relationship between functional connectivity using rich club (measured by MRI) and executive function in adults with d-TGA and if this relationship is modified by (a) presence of neuroresilience gene ApoE ε2or ε4 alleles or (b) damaging variants in hypoxia response genes.
Conditions
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Study Design
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NA
SINGLE_GROUP
OTHER
NONE
Study Groups
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Brain MRI
Obtain Brain MRI in adults with congenital heart disease and age/sex matched controls
MRI
Brain MRI
Interventions
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MRI
Brain MRI
Eligibility Criteria
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Inclusion Criteria
* Normally-developed age- and sex-matched young adults who are able to provide informed consent to undergo the MRI portion of the study and limited neuropsychological evaluation (IQ assessment as well as neuropsychological tests for which normative references are not available).
Exclusion Criteria
* Intellectual impairment precluding completion of the study questionnaires independently
* Unable to speak and read English fluently
24 Years
35 Years
ALL
Yes
Sponsors
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Boston Children's Hospital
OTHER
Responsible Party
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Michelle Gurvitz
Associate Professor
Locations
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Boston Children's Hospital
Boston, Massachusetts, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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P00039087
Identifier Type: -
Identifier Source: org_study_id
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